Preparation and investigation of bioactive transferrin-iron complexes formed with different synergistic anions.

Human serum transferrin has a potential for drug-delivery systems. Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis. Capillary zone electrophoresis and capillary isoelectric focusing were used to analyze the effectiveness of complexation reactions.

A possible explanation of the germicide effect of carbon dioxide in supercritical state based on molecular-biological evidence.

Supercritical carbon dioxide (CO(2)) possesses germicide (bactericide and sporicide) effect. Despite of the fact, that this effect is used in industrial sterilization processes, the sterilization mechanism at molecular level is unclear. Our hypotheses can provide a molecular-biological explanation for the phenomenon.