Comparison of the role of vitamin D in normal organs and those affected by COVID-19.

The outbreak of COVID-19 has opened up new avenues for exploring the importance of vitamin D in immunity, in addition to its role in calcium absorption. Recently, vitamin D supplementation has been found to enhance T regulatory lymphocytes, which are reduced in individuals with COVID-19. Increased risk of pneumonia and increases in inflammatory cytokines have been reported to be major threats associated with vitamin-D deficiency.

Effective BCDNet-based breast cancer classification model using hybrid deep learning with VGG16-based optimal feature extraction.

Problem: Breast cancer is a leading cause of death among women, and early detection is crucial for improving survival rates. The manual breast cancer diagnosis utilizes more time and is subjective. Also, the previous CAD models mostly depend on manmade visual details that are complex to generalize across ultrasound images utilizing distinct techniques.

Testis-Sparing Approach in Paratesticular Leiomyoma: A Rare Case Navigating From Diagnosis to Targeted Treatment Planning.

In this case study, we describe a 46-year-old male presenting with a palpable, gradually enlarging scrotal mass persisting over three to four years, ultimately diagnosed as paratesticular leiomyoma, who underwent enucleation of the tumor with no signs of recurrence, two years after surgery. This report underscores the significance of accurate diagnosis to avoid unnecessary treatment. We also emphasize the sequential events and findings, supported by relevant literature review, that contributed to establishing the correct diagnosis and guiding appropriate treatment decisions.

Rare Renal Malignancies: A Case Series Highlighting Uncommon Presentations and Their Management Strategies.

This case series elucidates renal cell carcinoma characterized by three distinct presentations, necessitating individualized treatment strategies tailored to each specific circumstance. The three cases presented pertain to clear cell renal cell carcinoma. The first case involves a 44-year-old male patient with renal cell carcinoma in an ectopic kidney, an exceedingly rare occurrence with limited literature.

Comparative investigation of structural properties and biological applications of chemical and biogenic synthesis of zirconium dioxide (ZrO) nanoparticles using Passiflora edulis.

Over the last decade, the environmental and wellness cost of antibiotic drug resistance to the societies have been astounding and require urgent attention Metal oxide nanomaterials have been achieved a pull-on deal with its entire applications in biological and photocatalytic applications. The present study conducts a comparative investigation on chemical and biogenic synthesis of zirconium dioxide (ZrO) nanoparticles aimed at enhancing their efficacy in their applications. The plant extract of Passiflora edulis act as a reducing and capping properties offering a sustainable and eco-friendly alternative.

Equine piroplasmosis in different geographical areas in France: Prevalence heterogeneity of asymptomatic carriers and low genetic diversity of Theileria equi and Babesia caballi.

Equine piroplasmosis is a worldwide tick-borne disease caused by the parasites Theileria equi sensu lato and Babesia caballi, with significant economic and sanitary consequences. These two parasites are genetically variable, with a potential impact on diagnostic accuracy. Our study aimed to evaluate the frequency of asymptomatic carriers of these parasites in France and describe the circulating genotypes.

The Future Hospital in Global Health Systems: The Future Hospital as an Entity.

Health care is changing rapidly. Hospitals are, and will remain, an essential setting to deliver it. We discuss how to maximise the benefits of hospitals in the future in different geographic and health system settings, highlighting a series of cross-cutting issues.

Adherence and forgiveness of two modern ART regimens: lamivudine/dolutegravir and emtricitabine/tenofovir alafenamide/rilpivirine.

Introduction: Few data are available about the forgiveness of two-drug (2DR) or low-barrier three-drug antiretroviral regimens. The aim of this study is to evaluate the real-life forgiveness of lamivudine/dolutegravir (3TC/DTG) and emtricitabine/tenofovir alafenamide/rilpivirine (FTC/TAF/RPV).

Methods: A two center retrospective observational study enrolled all people with HIV (PWH) treated with 3TC/DTG or FTC/TAF/RPV.

Quadrigeminal arachnoid cyst: Factors affecting outcomes and complications in a large series of cases.

Purpose: Arachnoid cysts constitute approximately 1 % of intracranial mass lesions, with quadrigeminal cistern arachnoid cysts being 5-18 % of those. This study presents a series of 31 cases of quadrigeminal cistern arachnoid cysts, constituting the most extensive series reported to date.

Methods: A retrospective analysis was conducted on 31 patients diagnosed with quadrigeminal cistern arachnoid cysts, focusing on clinical presentation, demographics, treatment approaches, and outcomes.

Reliability and validity of the revised indebtedness scale in Chinese university students.

The purpose of this study was to evaluate the psychometric properties of the Chinese version of the Revised Indebtedness Scale (IS-R-C) in mainland China. A total of 1057 university students participated in this study using a two-wave whole-group sampling method. Sample 1, consisting of 537 participants, was used for item analysis and exploratory factor analysis (EFA) of the Revised Indebtedness Scale (IS-R).

Gene expression & biochemical analysis in alkaptonuria caused by a founder pathogenic variant across different age groups from India.

Background & objectives Alkaptonuria (AKU) is an autosomal recessive disease wherein biallelic pathogenic variants in the homogentisate 1,2- dioxygenase (HGD) gene encoding the enzyme homogentisate 1,2 dioxygenase cause high levels of homogentisic acid (HGA) to circulate within the body leading to its deposition in connective tissues and excretion in urine. A homozygous splice donor variant (c.87+1G>A) has been identified to be the founder variant causing alkaptonuria among Narikuravars, a group of gypsies settled in Tamil Nadu.

Predictors of Mortality for Upper Extremity Penetrating Vascular Injuries (UEPVI).

Objectives: Our objective was to determine risk factors and operative outcomes for patients with upper extremity penetrating vascular injuries(UEPVI).

Methods: A retrospective review was performed of all adult UEPVI patients presenting to a level I trauma center between 1986 and 2019. Statistical analyses were performed to determine the independent predictors of mortality and hospital length of stay(LOS) among patients who underwent operative repair.

Multilingual SEIR public opinion propagation model with social enhancement mechanism and cross transmission mechanisms.

The propagation of public opinion in multilingual environments presents unique challenges due to the diversity of languages, cultures, and values. This study develops an SEIR-based model tailored for multilingual contexts, incorporating mechanisms such as social enhancement, forgetting, and cross-transmission. The model's purpose is to improve transparency, inclusivity, and effectiveness in public opinion management, particularly in diverse linguistic settings.

Influence of bio fillers on the characteristics of Luffa acutangula fiber reinforced polymer composites and parametric optimization using Taguchi technique.

Developing novel materials is an essential requirement in the engineering field. This study investigates the effects of incorporating wood dust particles on the mechanical and erosive wear properties of Luffa acutangula fiber (LAF)-reinforced phenol-formaldehyde composites, fabricated using the hand layup method with a constant 20% fiber content and varying wood dust particle contents of 0%, 10%, 20%, and 30%. Using the Taguchi method, the study identifies the optimal combination for minimizing erosive wear - 20% wood dust content, 45 m/s impact velocity, 60° impingement angle, 600 μm erodent size, and 60 mm standoff distance-achieving a minimum erosion rate of 189.

Comparing and assessing physical activity and sedentary behaviour guidelines for different populations with and without chronic conditions and/or disabilities: a systematic review protocol.

Physical activity guidelines targeting different populations with and without chronic diseases or disabilities are required to meet the diverse functional and physiological needs experienced by different subgroups of people to achieve optimal health benefits. As the importance of physical activity guidelines in promoting optimal health and well-being becomes increasingly recognised, there is a critical need for their systematic evaluation to ensure they remain effective, applicable and aligned with evolving health needs and scientific insights. This study aims to systematically review, critically evaluate, and compare global physical activity and sedentary behaviour guidelines on frequency, intensity, time, and type of exercise for adults, pregnant and postpartum women, and people living with chronic conditions and/or disabilities.

Differential gene expression profile in treated human gingival keratinocytes and their role in the development of HNSCC.

Background: Periodontitis is considered to be one of the major risk factors associated with cancers of the oral cavity. Periodontogenic pathogens such as and are the important pathogens associated with periodontitis. Chronic exposure to bacterial components induces changes in the nearby cells.

Intuition in Occupational Therapists' Clinical Reasoning: A Scoping Review.

This scoping review aimed to map the various facets of intuition in occupational therapy (OT), from its definitions, theoretical frameworks, epistemological paradigms to practical applications, highlighting its role in decision-making. Following the Joanna Briggs Institute methodology, a systematic search of five databases from 1990 to August 2023 identified 337 records related to OT and intuition. After removing duplicates and applying eligibility criteria, 22 studies were included.

Severe corneal manifestations of graft-versus-host disease: Experience of a tertiary referral center.

Purpose: Graft-versus-host disease (GVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). GVHD may affect several organs, including ocular manifestations, ranging from dry eye syndrome to sight-threatening corneal ulceration or perforation. Limited information is available about characteristics and treatments of ocular GVHD and its relation to general prognosis.

Outcomes of Total Thyroidectomy in Large Goiters With Retrosternal Extension and Tracheal Compression: A Multivariate Analysis.

Introduction: Large retrosternal goiters often cause tracheal compression and deviation, leading to respiratory symptoms and complicating surgical treatment. Total thyroidectomy is the treatment of choice though it carries a risk of complications due to the altered anatomy and its proximity to vital structures. This study examines the outcomes of total thyroidectomy in patients with retrosternal goiters and assesses the impact of tracheal compression on clinical results.

Comparative Evaluation of the Effect of Different Irrigation Regimens With and Without Ultrasonic Activation on Root Dentin Microhardness: An In Vitro Study.

Background The structural properties of dentin, including its microhardness, can be affected by exposure to endodontic irrigating solutions and ultrasonic activation. Aim The current study aimed to assess the effect of three different irrigation regimens, with and without ultrasonic activation, on the microhardness of the dentin. Methodology The research was conducted on 120 mandibular premolars randomly divided into four groups (n=30) based on the irrigation regimen, with each group further divided into two subgroups (n=15).

Unusual Canal Morphology in Mandibular Premolars With Two Distal and One Mesial Canal: A Case Series.

Mandibular premolars exhibit intricate and diverse root canal anatomy, presenting substantial challenges in endodontic treatment. Uncommon variations, such as the presence of three canals, demand meticulous diagnostic and therapeutic approaches to mitigate the risk of overlooking canals and subsequent treatment failure. This case report highlights three cases of mandibular premolars exhibiting a rare root canal configuration with one mesial and two distal canals, successfully managed using cone beam computed tomography (CBCT) for accurate diagnosis and ultrasonic activation for disinfection.

Signet-ring cell carcinoma of the transverse colon in a 10-year-old girl: A case report.

Background: Signet-ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer. The incidence of primary colonic SRCC is relatively rare in pediatric patients, with a limited number of reported cases currently available. The prognosis for this specific tumor type is unfavorable, and the preoperative diagnosis presents challenges, potentially leading to misdiagnosis.

Interventional surgery shows efficacy for diabetic patients withperipheral vascular disease.

Objective: To analyze the effect of interventional surgery on treatment efficacy and inflammatory cytokine (ICK) levels in diabetic patients with peripheral vascular disease (PVD).

Methods: A total of 116 diabetic patients with PVD admitted to the Second Affiliated Hospital of Guangzhou Medical University from August 2020 to March 2022 were selected for this retrospective analysis. Patients were divided into two groups: 58 patients receiving conventional medication were assigned to the control group, while 58 patients receiving interventional surgery in addition to conventional medication were assigned to the research group.

A Randomized Controlled Trial Assessing the Impact of Transcutaneous Electrical Acupoint Stimulation on Gastrointestinal Motility, Nutritional Status, and Immune Function in Patients Following Cerebrovascular Accident Surgery.

Background: Transcutaneous Electrical Acupoint Stimulation (TEAS) is a technique that involves stimulating specific acupoints on the body with electrical currents. It may regulate nerve excitability and improve nerve function. This study aimed to assess the impact of TEAS on gastrointestinal motility, nutrition, and immune function in patients post cerebrovascular accident surgery in the intensive care unit (ICU).