Publications by authors named "Csaba Filler"
The proper regeneration of vessel anastomoses in microvascular surgery is crucial for surgical safety. Pituitary adenylate cyclase-activating polypeptide (PACAP) can aid healing by decreasing inflammation, apoptosis and oxidative stress. In addition to hematological and hemorheological tests, we examined the biomechanical and histological features of vascular anastomoses with or without PACAP addition and/or using a hemostatic sponge (HS).
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- Valve calcification (VC) is common in chronic kidney disease (CKD) and involves valve interstitial cells (VICs) undergoing an osteogenic transition, with the hypoxia inducible factor (HIF) pathway playing a crucial but unclear role in this process.
- Research in CKD mice showed that high phosphate levels increased markers of osteogenic transition and HIF activation, leading to enhanced calcification in VICs, particularly under hypoxic conditions.
- The findings suggest that HIF activation contributes to VC via mechanisms involving reactive oxygen species and cell death, indicating that targeting the HIF pathway could be a potential therapeutic approach for treating aortic VC in CKD patients.