Publications by authors named "Csaba Boglari"
Article Synopsis
- Musashi RNA-binding proteins play key roles in stem cell maintenance, tumor formation, and development of the nervous system, with recent research highlighting their function in memory processes.
- In a study using C. elegans, human Musashi proteins (MSI1 and MSI2) were shown to restore memory-related phenotypes in worms with Musashi deficiencies, and inhibition of these proteins using (-)-gossypol improved memory retention without affecting other behaviors.
- The study concluded that targeting Musashi proteins pharmacologically could be a potential strategy for enhancing memory, especially in the context of age-related memory decline.
The Musashi family of RNA-binding proteins controls several biological processes including stem cell maintenance, cell division and neural function. Previously, we demonstrated that the C. elegans Musashi ortholog, msi-1, regulates forgetting via translational repression of the Arp2/3 actin-branching complex.
View Article and Find Full Text PDFThe identification of genes related to encoding, storage, and retrieval of memories is a major interest in neuroscience. In the current study, we analyzed the temporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in hermaphrodites. Here, we identified a core set of 712 (538 upregulated and 174 downregulated) genes that follows three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM.
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