Oseltamivir-Associated Bradycardia in Critically Ill Patients.

Background: Oseltamivir is frequently administered to critically ill patients with presumed influenza. It may modulate Na, K, and Ca channels to produce bradycardia.

Objective: To evaluate the association between oseltamivir and bradycardia in critically ill patients and assess parameters associated with bradycardia.

Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways.

Obesity is a risk factor for chronic kidney disease (CKD) progression. Circulating levels of adiponectin, an adipokine, decrease with obesity and play a protective role in the cardiovascular system. We hypothesized that adiponectin might also protect the kidney.