Executable Network Models of Integrated Multiomics Data.

Multiomics profiling provides a holistic picture of a condition being examined and captures the complexity of signaling events, beginning from the original cause (environmental or genetic), to downstream functional changes at multiple molecular layers. Pathway enrichment analysis has been used with multiomics data sets to characterize signaling mechanisms. However, technical and biological variability between these layered data limit an integrative computational analyses.

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy.

A 71-year-old woman collapsed while working as a grocery store cashier. CPR was performed and an AED revealed torsades de pointes (TdP). She was subsequently defibrillated resulting in restoration of sinus rhythm with a QTc interval of 544 msec.

Remote magnetic navigation for catheter ablation of atrioventricular nodal reentrant tachycardia: a systematic review and meta-analysis.

Catheter ablation has become a well-established, first-line therapy for atrioventricular nodal reentrant tachycardia (AVNRT), the most common reentry supraventricular tachycardia in humans. Robotic systems are becoming increasingly common in both complex and simple ablation procedures with presumed potential improvements in procedural efficacy and safety. The authors of this article conducted a systematic review and meta-analysis on the effectiveness and safety of the magnetic navigation system (MNS) in comparison with conventional catheter navigation for AVNRT ablation.

Determinants of pacemaker dependency after coronary and/or mitral or aortic valve surgery with long-term follow-up.

The aim of the present study was to investigate potential preoperative, operative, and postoperative predictors of pacemaker (PM) dependency after coronary, mitral valve, and aortic valve surgery. One hundred two patients (mean age 68 +/- 11 years; 62% men) who had received a permanent PM after cardiac surgery were included. The presence of any pacing activity in VVI mode with a lower rate of 30 beats/min was defined as PM dependency.

Meta-analysis of magnesium therapy for the acute management of rapid atrial fibrillation.

The profile of electrophysiologic effects of magnesium on the heart suggests that magnesium might be effective in the treatment of atrial fibrillation (AF) in terms of rhythm and rate control. We aimed to investigate the efficacy of magnesium administration in the acute treatment of rapid AF. Randomized controlled trials comparing intravenous magnesium versus placebo or antiarrhythmic agents for the acute management of rapid AF were included.