Publications by authors named "Crystal A Haeussler"
Article Synopsis
- - This study examined concussion severity and outcomes in children involved in various activities (e.g., non-sport trauma, organized sports, and recreational activities) by measuring glial and neuronal biomarkers GFAP and UCH-L1.
- - A total of 131 participants with concussions were enrolled, revealing significant differences in GFAP and UCH-L1 levels across groups, suggesting variations in concussion severity based on the type of activity.
- - CT scans showed intracranial lesions in a small percentage of cases, and elevated UCH-L1 levels were linked to poorer outcomes, indicating that while concussion severity and outcomes appeared similar across groups, biomarker levels provide insights into the extent of injury.
Objectives: To evaluate the ability of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) to detect concussion in children and adult trauma patients with a normal mental status and assess biomarker concentrations over time as gradients of injury in concussive and non-concussive head and body trauma.
Design: Large prospective cohort study.
Setting: Three level I trauma centres in the USA.
This study examined the performance of serum ubiquitin C-terminal hydrolase (UCH-L1) in detecting traumatic intracranial lesions on computed tomography (CT) scan (+CT) in children and youth with mild and moderate TBI (mmTBI) and assessed its performance in trauma control patients without head trauma. This prospective cohort study enrolled children and youth presenting to three level 1 trauma centers after blunt head trauma and a Glasgow Coma Scale (GCS) score of 9-15 as well as trauma control patients with GCS 15 that did not have blunt head trauma. The primary outcome measure was the presence of intracranial lesions on initial CT scan.
View Article and Find Full Text PDFImportance: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been widely studied and show promise for clinical usefulness in suspected traumatic brain injury (TBI) and concussion. Understanding their diagnostic accuracy over time will help translate them into clinical practice.
Objectives: To evaluate the temporal profiles of GFAP and UCH-L1 in a large cohort of trauma patients seen at the emergency department and to assess their diagnostic accuracy over time, both individually and in combination, for detecting mild to moderate TBI (MMTBI), traumatic intracranial lesions on head computed tomography (CT), and neurosurgical intervention.