Bis[2,3-bis-(thio-phen-2-yl)pyrido[3,4-]pyrazine]-silver(I) perchlorate methanol disolvate.

The title compound, [Ag(CHNS)]ClO·2CHOH, is monoclinic. The Ag atom is coordinated by pyrido N atoms and is two-coordinate; however, the Ag atom has nearby O atoms that can be assumed to be weakly bonded - one from the perchlorate anion and one from the methanol solvate molecule. One of the thienyl groups on a 2,3-bis-(thio-phen-2-yl)pyrido[3,4-]pyrazine is flipped disordered and was refined to occupancies of 68.

Poly[(μ-2,3-diethyl-7,8-di-methyl-quinoxaline-κ:)(2,3-diethyl-7,8-di-methyl-quinoxaline-κ)-μ-nitrato-κ:'-nitrato-κ,'-disilver(I)].

The structure of the title compound, [CHN)Ag](NO), contains subtle differences in ligand, metal, and counter-anion coordination. One quinoxaline ligand uses one of its quinoxaline N atoms to bond to one silver cation. That silver cation is bound to a second quinoxaline which, in turn, is bound to a second silver atom; thereby using both of its quinoxaline N atoms.

Bis[μ-bis-(pyridin-2-yl)methanone oxime-κ:,','']bis-[di-acetato-κ,';κ-zinc(II)].

The structure of the title complex, [Zn(CHO)(CHNO)], is triclinic containing half of the mol-ecule in the asymmetric unit. Each zinc atom is coordinated to a pyridyl and oxime nitro-gen from one di-2-pyridyl ketone oxime (dpko) ligand and a third nitro-gen from the other dpko pyridyl ring. Additionally, each zinc is coordinated to two acetato anions, one of which is bidentate and the other monodentate.

Bis[5-methyl-2,3-bis-(thio-phen-2-yl)quinoxaline-κ](nitrato-κ,')silver(I).

The crystal structure of the title silver(I) complex, [Ag(NO)(CHNS)], has monoclinic (2/) symmetry, with the silver(I) atom and the nitrate group sitting on a twofold rotation axis. The complex also exhibits a thienyl-ring flip disorder, which is common for unsubstituted thio-phene rings.

Bis[2-(thio-phen-2-yl)quinoxaline-κ]silver(I) perchlorate.

The crystal of the title salt, [Ag(CHNS)]ClO, has 2/ symmetry whereby the silver(I) atom sits on a twofold rotation axis, as does the perchlorate anion, which is disordered about this axis. The thienylquinoxaline ligand is nearly planar with the thienyl ring making a dihedral angle of 10.88 (8)° with respect to the quinoxaline moiety.

Anatomical and audiological considerations in branchiootorenal syndrome: A systematic review.

Objective: Establish anatomical considerations, audiological outcomes, and optimal management in patients with branchiootic/branchiootorenal syndrome (BO/BOR).

Methods: Databases reviewed: Medline, Pubmed, Embase, Web of Science, Cochrane Collection, and ClinicalTrials.gov.

Cochlear Implantation in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome: Case Presentation.

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome is a multisystem, progressive neurodegenerative condition, and the most common mitochondrial cytopathy. While not a primary characteristic, sensorineural hearing loss is a common additional symptom reported in up to 78% of cases. This article presents 2 cases of cochlear implantation in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome.

Acute otitis externa: Consensus definition, diagnostic criteria and core outcome set development.

Objective: Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop 1) a definition, 2) diagnostic criteria and 3) a core outcome set (COS) for AOE.

Study Design: COS development according to Core Outcome Measures in Effectiveness Trials (COMET) methodology and parallel consensus selection of diagnostic criteria/definition.

Outcomes of Cochlear Implantation in Patients with Superficial Siderosis: A Systematic Review and Narrative Synthesis.

This study aimed to establish outcomes following cochlear implantation (CI) in patients with superficial siderosis (SS). MEDLINE, Embase, Web of Science, Cochrane, and ClinicalTrials.gov databases were searched for this systematic review.

2,3-Di-ethyl-benzo[]quinoxaline.

The title compound, CHN, was synthesized by dispersing 3,4-hexa-nedione in a methanol-water solution containing the acid catalyst NHHF, then adding 1,2-di-aminona-phthalene. The fused-ring system of the title compound is close to planar (r.m.

Tetra-aqua-[3-oxo-1,3-bis-(pyridinium-2-yl)propan-1-olato]nickel(II) tribromide dihydrate.

The crystal structure of the title compound, [Ni(CHNO)(HO)]Br·2HO, contains an octa-hedral Ni atom coordinated to the enol form of 1,3-di-pyridyl-propane-1,3-dione (dppo) and four water mol-ecules. Both pyridyl rings on the ligand are protonated, forming pyridinium rings and creating an overall ligand charge of +1. The protonated nitro-gen-containing rings are involved in hydrogen-bonding inter-actions with neighoring bromide anions.

6-Nitro-2,3-bis-(thio-phen-2-yl)quinoxaline.

The title compound, CHNOS, was synthesized a condensation reaction in refluxing acetic acid. One thienyl ring is nearly coplanar with the quinoxaline unit [dihedral angle = 3.29 (9)°], the other makes an angle of 83.

5-Nitro-2,3-bis-(thio-phen-2-yl)quinoxaline.

The title compound, CHNOS, was synthesized a condensation reaction in refluxing acetic acid. The dihedral angles between the mean plane of the quinoxaline unit and the thienyl rings are 35.16 (5)° and 24.

Crystal structures of 2,3-bis-(thio-phen-2-yl)pyrido[2,3-]pyrazine and 7-bromo-2,3-bis-(thio-phen-2-yl)pyrido[2,3-]pyrazine.

The crystal structures of 2,3-bis-(thio-phen-2-yl)pyrido[2,3-]pyrazine, CHNS (), and 7-bromo-2,3-bis-(thio-phen-2-yl)pyrido[2,3-]pyrazine, CHBrNS (), are discussed. Both mol-ecules crystallize in space group 2/. In , the thienyl rings are inclined to the mean plane of the pyrido-pyrazine moiety by 6.

The Impact of Single-Sided Deafness upon Music Appreciation.

Background: Many of the world's population have hearing loss in one ear; current statistics indicate that up to 10% of the population may be affected. Although the detrimental impact of bilateral hearing loss, hearing aids, and cochlear implants upon music appreciation is well recognized, studies on the influence of single-sided deafness (SSD) are sparse.

Purpose: We sought to investigate whether a single-sided hearing loss can cause problems with music appreciation, despite normal hearing in the other ear.

Cochlear implants in the management of hearing loss in Neurofibromatosis Type 2.

Objective: Review of cochlear implant (CI) outcomes in patients with Neurofibromatosis Type 2 (NF2), implanted in the presence of an ipsilateral vestibular schwannoma (VS). Hearing restoration was combined in some cases with a Bevacizumab regime.

Method: Retrospective review of 12 patients, managed over the period 2009-2016, at a tertiary referral multidisciplinary NF2 clinic.

Attitudes towards and personal use of complementary and alternative medicine amongst clinicians working in audiovestibular disciplines.

Objective: Literature indicates that complementary and alternative medicine is used by patients with auditory and vestibular symptoms. This study sought to determine the prevalence of complementary and alternative medicine uptake, and examine attitudes towards complementary and alternative medicine in clinicians working with audiovestibular disorder patients.

Method: The Holistic Complementary and Alternative Medicine Questionnaire and a devised questionnaire about recent and lifetime use of complementary and alternative medicine were used.

Ototoxicity (cochleotoxicity) classifications: A review.

Objective: Drug-mediated ototoxicity, specifically cochleotoxicity, is a concern for patients receiving medications for the treatment of serious illness. A number of classification schemes exist, most of which are based on pure-tone audiometry, in order to assist non-audiological/non-otological specialists in the identification and monitoring of iatrogenic hearing loss. This review identifies the primary classification systems used in cochleototoxicity monitoring.

Crystal structure of N,N'-[(thio-phene-2,5-di-yl)bis-(methanylyl-idene)]di-p-toluidine.

The title compound, C20H18N2S, was synthesized by the condensation reaction between p-tolu-idine and thio-phene-2,5-dicarboxaldehye in refluxing toluene with p-toluene-sulfonic acid added as catalyst. The mol-ecule lies on a twofold rotation axis and adopts an E orientation with respect to the azomethine bonds. The dihedral angle between the unqiue benzene ring and the least-squares plane [maximum deviation = 0.

Crystal structure of hexa-aqua-dichlorido-ytterbium(III) chloride.

The crystal structure of the title compound, [YbCl2(H2O)6]Cl, was determined at 110 K. Samples were obtained from evaporated aceto-nitrile solutions containing the title compound, which consists of a [YbCl2(H2O)6](+) cation and a Cl(-) anion. The cations in the title compound sit on a twofold axis and form O-H⋯Cl hydrogen bonds with the nearby Cl(-) anion.

6,7-Di-chloro-2,3-bis(pyridin-2-yl)quinox-aline.

The title compound, C18H10Cl2N4, synthesized by the condensation reaction between 4,5-di-chloro-benzene-1,2-di-amine and 1,2-di(pyridin-2-yl)ethane-1,2-dione in boiling acetic acid, has a nearly planar quinoxaline moiety [maximum deviation = 0.070 (1) Å] whose mean plane makes dihedral angles of 40.51 (2) and 39.

Images of otoscopy: rate and extent of non-compliance with good practice standards.

Background: The British Society of Audiology has produced clear guidelines as to how otoscopy should be undertaken; however, no nationally recognised guidelines exist for the wider clinical community. Images of otoscopy appear in many books, journals, magazines and websites.

Objective: This study aimed to determine the rate of non-compliance with good practice in images of otoscopy, the seriousness of the breach, and whether this is more common in sites for professionals or the general public.

Treatment of superficial siderosis with iron chelation therapy.

Superficial siderosis is caused by recurrent haemorrhage in the subarachnoid space leading to haemosiderin deposition. It typically causes the triad of ataxia, deafness and myelopathy. We report a patient who developed superficial siderosis following neurosurgery for syringomyelia and who had an improvement in his hearing and mobility following treatment with a new iron chelation therapy that can penetrate the blood-brain barrier.

2,3-Bis(thio-phen-3-yl)quinoxaline.

In the title compound, C16H10N2S2, the thienyl rings are inclined to one another by 62.71 (10)°, and are inclined by 63.94 (8) and 21.

Bis[2-(thio-phen-2-yl)quinoxaline-κN (4)]silver(I) tetra-fluoridoborate.

In the title compound, [Ag(C12H8N2S)2]BF4, the two-coordinate Ag(I) ion lies on a crystallographic inversion center and is linearly bonded to the N-donor atoms of two separate quinoxaline ligands. The thio-phenyl ring of the ligand is nearly coplanar with the quinoxaline ring system [dihedral angle = 9.15 (13)°].