Publications by authors named "Crowson C"
Objective: Determine whether pollutants such as fire smoke-related particulate matter smaller than 2.5 microns (PM) are associated with incident rheumatoid arthritis (RA) and RA-associated interstitial lung disease (RA-ILD).
Methods: This case-control study used Veterans Affairs data 10/1/2009-12/31/2018.
Objective: To characterise the changing trends in the pharmacological management of SLE in the USA between 2007 and 2023 as new treatment options emerged.
Methods: In a retrospective cohort study using data from OptumLabs Data Warehouse, we characterised the annual prevalent (ie, all) and incident (ie, new) use of antimalarials, glucocorticoids and immunosuppressive medications among patients with SLE from 2007 to 2023 and assessed for changing trends over time.
Results: We identified 19 122 adults with SLE; they were 51.
Objective: The 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria score (≥20 points) has been associated with poor outcomes. We aimed to evaluate its utility as a predictor for mortality and hospitalisation and to derive and validate an ominosity score based on the SLE classification criteria set.
Methods: Incident patients with SLE in a population-based cohort were included.
Article Synopsis
- The study sought to identify specific genetic-respiratory disease interactions that increase the risk of developing rheumatoid arthritis (RA).
- Using case-control data from Mass General Brigham and the Mayo Clinic, researchers found significant associations between certain respiratory diseases and RA risk, with particular genetic factors influencing this relationship.
- The results suggest that understanding these genetic-respiratory interactions could lead to more personalized approaches for preventing, diagnosing, and treating RA in the future.
Objective: Polymyalgia rheumatica (PMR) is an inflammatory disorder of the elderly characterized by girdle pain and stiffness. Obesity has an influence on disease activity and outcome in rheumatic diseases like osteoarthritis and rheumatoid arthritis. We aimed to investigate the relationship between high BMI and the severity and outcome of PMR, which is incompletely understood.
View Article and Find Full Text PDFObjective: The aim of this study was to characterize the phenotype and genotype of patients with Yao syndrome (YAOS), with focus on comparing to prior cohorts, identifying novel features, and describing treatment observations.
Methods: A retrospective medical records review of patients with YAOS seen at Mayo Clinic was conducted to characterize clinical features, genotypes, and therapeutic trials and responses.
Results: Twenty-two patients diagnosed with YAOS were included.
Objective: To examine the role of cardiovascular disease (CVD) as a mediator in the pathway between rheumatoid arthritis (RA) and Alzheimer's disease and related dementias (ADRD).
Methods: This retrospective population-based study included patients over 50 years of age with incident RA, who met the 1987 ACR criteria in 1980-2014. This cohort was matched 1:1 on age, sex and index year to comparators without RA.
Article Synopsis
- The study aimed to explore the trends of depression and anxiety among individuals with rheumatoid arthritis (RA) over a 30-year period, comparing them to matched non-RA individuals.
- Researchers analyzed data from 1012 patients with RA and matched controls, finding that anxiety and co-occurring anxiety and depression increased significantly from 2005-2014 compared to 1985-1994, particularly in seropositive RA patients.
- The findings highlight a growing concern for mental health among RA patients, suggesting an increased need for clinicians to address these rising rates of anxiety and depression.
Clinical Presentation, Care Pathways, and Delays in Access to Specialized Care in Patients With Systemic Lupus Erythematosus: A Study From Lupus Midwest Network (LUMEN).
Arthritis Care Res (Hoboken)
October 2024
Objective: We aimed to characterize presentation and care pathways of patients with systemic lupus erythematosus (SLE), and delays in access to SLE-specialized care.
Methods: We included patients with incident SLE from the Lupus Midwest Network registry. Time from the first medical encounter for SLE clinical manifestation to access to SLE-specialized care, physician diagnosis, and treatment was estimated.
Peer review is an essential process in scientific research, ensuring the comprehensiveness, accuracy, and suitability of manuscripts for publication. Neurology education research differs from biomedical clinical research in several ways. These differences encompass specific paradigms, the use of theoretical frameworks, and different methodological approaches.
View Article and Find Full Text PDFObjectives: To examine the clinicopathologic features of patients with polymyalgia rheumatica (PMR) who had thoracic aorta repair surgery. Findings were compared with those of a cohort of patients with giant cell arteritis (GCA) requiring thoracic aorta repair.
Methods: All patients evaluated at Mayo Clinic in Rochester, MN, with Current Procedural Terminology (CPT) codes for thoracic aorta repair surgery between 2000- 2021 were identified.
Objective: Rheumatoid arthritis (RA) has been associated with an elevated dementia risk. This study aimed to examine how different diagnostic dementia definitions perform in patients with RA compared to individuals without RA.
Methods: The study population included 2050 individuals (1025 with RA) from a retrospective, population-based cohort in southern Minnesota and compared the performance of 3 code-based dementia diagnostic algorithms with medical record review diagnosis of dementia.
Impact of Glucocorticoid Dose on Complete Response, Serious Infections, and Mortality During the Initial Therapy of Lupus Nephritis: A Systematic Review and Meta-Analysis of the Control Arms of Randomized Controlled Trials.
Arthritis Rheumatol
September 2024
Objective: Our objective was to evaluate the effect of glucocorticoid regimens on renal response, infections, and mortality among patients with lupus nephritis (LN).
Methods: We performed a systematic review and meta-analysis of the control arms of randomized clinical trials (RCTs). We included RCTs of biopsy-proven LN that used a protocolized regimen of glucocorticoids in combination with mycophenolic acid analogs or cyclophosphamide and reported the outcomes of complete response (CR), serious infections, and death.
Objectives: To determine whether antecedent sinusitis is associated with incident rheumatic disease.
Methods: This population-based case-control study included all individuals meeting classification criteria for rheumatic diseases between 1995 and 2014. We matched three controls to each case on age, sex and length of prior electronic health record history.
Objectives: We aimed to cluster patients with rheumatoid arthritis (RA) based on comorbidities and then examine the association between these clusters and RA disease activity and mortality.
Methods: In this population-based study, residents of an eight-county region with prevalent RA on 1 January 2015 were identified. Patients were followed for vital status until death, last contact or 31 December 2021.
Objectives: To examine multimorbidity in psoriasis and its association with the development of PsA.
Methods: A retrospective cohort study was performed using the Rochester Epidemiology Project. Population-based incidence (2000-2009) and prevalence (Jan 1, 2010) cohorts of psoriasis were identified by manual chart review.
Article Synopsis
- Adrenal hemorrhage (AH) is a serious condition linked to antiphospholipid Syndrome (APS), affecting primarily middle-aged adults, and leading to complications like primary adrenal insufficiency and increased mortality rates.
- A study analyzed 256 patients with APS-AH, finding that 69% had bilateral adrenal involvement and common symptoms included abdominal pain, nausea, and vomiting, with hyponatremia as the prevalent electrolyte disorder.
- The five-year survival rate was 82%, but a history of stroke significantly increased the risk of mortality, highlighting the need for careful monitoring and treatment strategies in affected patients.
Objective: To assess the association between a comprehensive list of morbidities and serious infection (SI) in patients with rheumatoid arthritis (RA).
Methods: This study evaluated SI risk associated with 55 comorbidities using a population-based inception cohort including all adult patients with incident RA from 1999 through 2014 with follow up through 2021. Morbidities and SI were ascertained using previously validated international classification of disease (ICD)-9 and ICD-10 codes.
Article Synopsis
- - Levels of circulating calprotectin are higher in primary antiphospholipid syndrome (APS) patients compared to healthy controls, indicating its potential role in the condition.
- - The study revealed calprotectin's association with increased neutrophil counts and C-reactive protein levels, while showing a negative correlation with platelet counts, suggesting its involvement in thrombocytopenia.
- - Mechanistic insights suggested that calprotectin may trigger aPL-mediated thrombocytopenia by activating platelet surface receptors and the NLRP3-inflammasome, leading to reduced platelet viability.
Objective: We aimed to evaluate the robustness of phase III randomised controlled trials (RCTs) for SLE and lupus nephritis (LN) using the fragility index (FI), the reverse FI (RFI) and the fragility quotient (FQ).
Methods: We searched for phase III RCTs that included patients with active SLE or LN. Data on primary endpoints, total participants and the number of events for each arm were obtained.
Objectives: The objectives of this study were to assess the prevalence and incidence of multimorbidity and its association with the SLICC/ACR damage index (SDI) among patients with SLE.
Methods: Using prevalent and incident population-based cohorts of patients with SLE and their matched comparators, we assessed 57 chronic conditions. Chronic conditions were categorized as SDI-related or SDI-unrelated.
Objectives: To examine the association of multimorbidity phenotypes at baseline with disease activity and functional status over time in ankylosing spondylitis (AS).
Methods: Patient-reported AS morbidities (comorbidities, N = 28 and extra-musculoskeletal manifestations, EMMs, N = 3) within 3 years of enrollment with a prevalence ≥1 %, were included from the Prospective Study of Outcomes in Ankylosing Spondylitis (PSOAS) cohort. We defined multimorbidity as ≥2 morbidities (MM2+) and substantial multimorbidity as ≥5 morbidities (MM5+).
Objectives: The objective is to examine utilisation of cardiovascular preventive services in patients with rheumatoid arthritis (RA), compared with a non-RA population, and to examine cardiovascular disease (CVD) screening rates among RA patients without diabetes mellitus (DM), hypertension or hyperlipidaemia to non-RA patients with one of these diagnoses.
Methods: All ≥18-year-old patients with an RA diagnosis living in one of eight Minnesota counties on 1 January 2015 were included and matched (1:1) by sex, age and county to non-RA comparators. Rates of screening for CVD risk factors, including DM (ie, glucose), hypertension (ie, blood pressure) and hyperlipidaemia (ie, lipids), were compared between groups using Cox models.
Objectives: Active RA has been associated with an increased risk of both cardiovascular and peripheral vascular disease. We aimed to compare cerebrovascular changes in patients with and without RA, both with and without a neuropathologic diagnosis of neurodegenerative disease.
Methods: Patients with RA (n = 32) who died and underwent autopsy between 1994 and 2021 were matched to non-RA controls (n = 32) on age, sex and level of neurodegenerative proteinopathy.
Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review.
Clin Immunol
November 2023
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disease linked to blood clots and pregnancy complications, with severe cases sometimes causing diffuse alveolar hemorrhage (DAH).
- A study analyzed data from 219 patients with APS-associated DAH to identify clinical features, treatments, and factors affecting patient outcomes, using various statistical methods for assessment.
- Findings showed a high relapse rate (47% at six months) and significant mortality rates (30.3% at one year), with severe thrombocytopenia, valve vegetations, and catastrophic APS being linked to higher mortality risk.