Publications by authors named "Crowder H"
Facial nerve dysfunction (FND) is a well-recognized but poorly documented complication of mandibular distraction osteogenesis (MDO) for Robin sequence (RS). This study aims to document the authors' experiences with FND and identify risk factors associated with this adverse event. A retrospective review of a prospectively gathered database was performed to identify patients with RS who underwent MDO at the authors' institution from March 2016 to June 2023.
View Article and Find Full Text PDFObjective: Evaluate infants with Robin Sequence (RS) who were successfully treated with conservative airway measures alone vs. those who failed and eventually underwent surgical airway intervention after a protracted course of conservative management.
Design: Retrospective review of prospectively gathered database.
Article Synopsis
- This study evaluates factors that may lead to the need for additional imaging to diagnose peritonsillar abscesses (PTA) after an ultrasound.
- Among 411 patients reviewed, those requiring further imaging were younger and had more limited neck movement, which was linked to longer hospital stays and a higher likelihood of surgery.
- The findings highlight specific characteristics that could predict which patients might need secondary imaging, suggesting that while ultrasound is effective, supplementary imaging can be beneficial in certain cases.
Article Synopsis
- Deep learning (DL) models for automatic segmentation can save time but need extensive fine-tuning for new datasets; this study evaluates their ability to work without such adjustments.
- The researchers tested pretrained DL models on different datasets that varied by scanner type and patient characteristics, including healthy individuals and those with knee issues.
- Results showed that the DL model trained specifically on qDESS data outperformed the one trained on Osteoarthritis Initiative data in terms of segmentation accuracy and agreement with manual measurements.
Normocephalic sagittal craniosynostosis in young children is common and unrecognized.
Childs Nerv Syst
August 2022
Objective: Sagittal craniosynostosis (SC) is usually diagnosed during early childhood by the presence of scaphocephaly. Recently, our group found 3.3% of children under 5 years of age with normocephalic sagittal craniosynostosis (NSC) using computed tomography (CT) scans.
View Article and Find Full Text PDFBackground: Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation.
Methods: All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment.
Results: The UW-QOL surveys were received from 25 of 48 eligible patients (52.
Objective: Collect data from craniofacial surgeons to analyze mandibular distraction osteogenesis (MDO) protocols, and facial nerve dysfunction (FND) to characterize this common, but poorly documented complication after MDO in infants with Robin Sequence (RS).
Design, Setting, And Participants: A 16-question anonymous survey designed through REDCap was digitally distributed to members of the American Cleft Palate-Craniofacial Association and International Society of Craniofacial Surgery (ISCFS).
Main Outcome Measure(s): Demographic information, MDO perioperative variables, surgeon experience with FND after MDO for patients with RS, and the timing and duration of FND were analyzed.
Objective: Robin Sequence (RS), characterized by micrognathia, glossoptosis, and upper airway obstruction, is an increasingly recognized diagnosis. An effective surgical intervention is mandibular distraction osteogenesis (MDO). This study analyzes published evidence regarding facial nerve dysfunction (FND) associated with MDO.
View Article and Find Full Text PDFObjective: To evaluate 2-year follow-up swallowing function in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) who completed neoadjuvant chemotherapy and transoral robotic surgery (NAC+S).
Study Design: Retrospective analysis of patients with OPSCC treated with NAC+S between 2010 and 2021.
Setting: A single academic institution.
Objective: The novel coronavirus (COVID-19) forced unprecedented changes in pediatric otolaryngology workflow in the early pandemic, particularly due to the postponement of elective procedures. In turn, this has impacted timely treatment of patients and ability to train residents and fellows. The objective is to characterize how surgical practices in pediatric otolaryngology have been impacted by the pandemic through a cross sectional analysis over three years.
View Article and Find Full Text PDFObjective: To review current literature describing the management of temporomandibular disorder (TMD) and to propose an evidence-based algorithm for otolaryngologists.
Data Sources: A literature review using PubMed and Scopus was conducted to identify manuscripts that describe TMJ disorder etiology, diagnostic methods, and management across the fields of otolaryngology, general practice medicine, physical therapy, dentistry, and maxillofacial surgery.
Review Methods: Two reviewers subjectively evaluated the studies based on the inclusion criteria, incorporating them into a comprehensive algorithm.
Background: Thymectomy is traditionally performed through a transsternal incision, but less invasive modalities have emerged, including transcervical, thoracoscopic, and robotic approaches. Despite the advantages of video-assisted thoracoscopic surgery (VATS) over thoracotomy, most thymectomies are performed through sternotomy. This study compared the use and 30-day postoperative outcomes of transsternal, transcervical, and VATS thymectomy in the Veterans Health Administration.
View Article and Find Full Text PDFAdverse events associated with Bonebridge and Osia bone conduction implant devices.
Am J Otolaryngol
November 2021
Purpose: Active transcutaneous Bone Conduction Implants (BCIs) are relatively new to the market and may offer improved outcomes while reducing skin-related complications associated with previous models. The purpose of this study is to examine medical device reports (MDRs) submitted to the Food and Drug Administration's (FDA) Manufacturer and User Device Facility Experience (MAUDE) database to identify adverse events with the active, transcutaneous BCIs, Bonebridge and Osia.
Methods: A search of the FDA MAUDE database was conducted using product code "PFO" (for Active Implantable Bone Conduction Hearing System), brand names "Bonebridge" and "Osia.
Cartilage transmits and redistributes biomechanical loads in the knee joint during exercise. Exercise-induced loading alters cartilage hydration and is detectable using quantitative magnetic resonance imaging (MRI), where T relaxation time (T ) is influenced by cartilage collagen composition, fiber orientation, and changes in the extracellular matrix. This study characterized short-term transient responses of healthy knee cartilage to running-induced loading using bilateral scans and image registration.
View Article and Find Full Text PDFNon-ionic CT contrast solutions rapidly alter bovine cartilage and meniscus mechanics.
Osteoarthritis Cartilage
September 2020
Objective: To evaluate effects of a common CT contrast agent (iohexol) on the mechanical behaviors of cartilage and meniscus.
Methods: Indentation responses of juvenile bovine cartilage and meniscus were monitored following exposure to undiluted contrast agent (100% CA), 50% CA/water, 50% CA/Phosphate Buffered Saline (PBS) or PBS alone, and during re-equilibration in PBS. The normalized peak force (F¯), effective osmotic strain (ε), and normalized effective contact modulus (E¯) were calculated for every cycle, with time constants determined for both exposure and recovery via mono- or biexponential fits to F¯.
We evaluated compliance with submitting a short Web-based personal behavior survey daily during a 10-week study (n = 52 women/3419 diaries). Time-stamped forms revealed that 50% of diaries were submitted within 24 hours of the email prompt, and 19% were missing or submitted more than 3 days late. Late submissions may affect data quality.
View Article and Find Full Text PDFArticle Synopsis
- Canonical pre-mRNA splicing typically requires certain proteins (snRNPs) to remove long introns, but non-canonical splicing has been observed for some short introns in tRNAs and mRNAs, like XBP1.
- Researchers in this study developed a method to identify short introns using RNA-Seq data, finding hundreds of conserved short introns across different human cell types that are often alternatively spliced.
- The study reveals that splicing efficiency for these short introns can be enhanced by their secondary structures, and their removal can change the reading frame of mRNAs, indicating that current gene prediction models may not effectively account for these introns in the human transcriptome.
Objective: To measure the effect of intranasal desmopressin (l-deamino 8-D-arginine vasopressin, DDAVP) on urine osmolality in a group of patients with persistent primary enuresis, and to determine whether changes in osmolality can the predict response to treatment.
Patients And Methods: Thirty-seven patients with persistent primary nocturnal enuresis were entered into a double-blind placebo-controlled crossover trial of 20 micrograms intranasal DDAVP spray. Morning urinary osmolality was measured on two occasions during each phase of treatment and the clinical response recorded in a diary.