Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release.

Myotonic dystrophy type 2 (DM2) is a tetranucleotide CCTG repeat expansion disease associated with an increased prevalence of autoimmunity. Here, we identified an elevated type I interferon (IFN) signature in peripheral blood mononuclear cells and primary fibroblasts of DM2 patients as a trigger of chronic immune stimulation. Although RNA-repeat accumulation was prevalent in the cytosol of DM2-patient fibroblasts, type-I IFN release did not depend on innate RNA immune sensors but rather the DNA sensor cGAS and the prevalence of mitochondrial DNA (mtDNA) in the cytoplasm.

FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction.

The mitochondrial integrated stress response (mitoISR) has emerged as a major adaptive pathway to respiratory chain deficiency, but both the tissue specificity of its regulation, and how mitoISR adapts to different levels of mitochondrial dysfunction are largely unknown. Here, we report that diverse levels of mitochondrial cardiomyopathy activate mitoISR, including high production of FGF21, a cytokine with both paracrine and endocrine function, shown to be induced by respiratory chain dysfunction. Although being fully dispensable for the cell-autonomous and systemic responses to severe mitochondrial cardiomyopathy, in the conditions of mild-to-moderate cardiac OXPHOS dysfunction, FGF21 regulates a portion of mitoISR.

Identification of the Beagle 2 lander on Mars.

The 2003 Beagle 2 Mars lander has been identified in Isidis Planitia at 90.43° E, 11.53° N, close to the predicted target of 90.

Bias in Point Estimates and Standard Errors of Mokken's Scalability Coefficients.

Mokken scale analysis uses three types of scalability coefficients to assess the quality of (a) pairs of items, (b) individual items, and (c) an entire scale. Both the point estimates and the standard errors of the scalability coefficients assume that the sample ordering of the item steps is identical to the population ordering, but due to sampling error, the sample ordering may be incorrect and, consequently, the estimates and the standard errors may be biased. Two simulation studies were used to investigate the bias of the estimates and the standard errors of the scalability coefficients, as well as the coverage of the 95% confidence intervals.

The role of sex and autonomy-connectedness in internalizing and externalizing personality pathology, coping and axis-I pathology: among psychiatric and healthy elderly.

Objectives: In the current study we investigated the relationship of sex and autonomy-connectedness with internalizing and externalizing personality disorder symptoms (PDS), coping and axis-I pathology in older age.

Method: A path model was tested which was based on neo-analytical object relation, attachment- and primary-personality theory, among 100 clinical and 106 non-clinical elderly.

Results: In line with our model, autonomy-connectedness (self-awareness and capacity of managing new situations) was strongly associated to internalizing PDS in both groups.

Stepwise Latent Class Models for Explaining Group-Level Outcomes Using Discrete Individual-Level Predictors.

Explaining group-level outcomes from individual-level predictors requires aggregating the individual-level scores to the group level and correcting the group-level estimates for measurement errors in the aggregated scores. However, for discrete variables it is not clear how to perform the aggregation and correction. It is shown how stepwise latent class analysis can be used to do this.

The role of sex, attachment and autonomy-connectedness in personality functioning.

Previous studies have found significant relationships among sex, attachment and autonomy-connectedness and DSM-IV personality characteristics. In the present study, we aimed to add to the current knowledge about attachment-related aspects of personality pathology, by examining the relationships of these same variables with dimensions of pathological personality structure as conceptualized by Kernberg. The study was performed among 106 ambulatory patients from a Dutch mental healthcare institute.

Evaluation of a recovery-oriented care training program for mental healthcare professionals: effects on mental health consumer outcomes.

Objectives: To examine the effects of a recovery-oriented care training program for mental healthcare professionals on mental health consumer outcomes.

Methods: The Mental Health Recovery Measure (MHRM) and the Recovery-Promoting Relationship Scale (RPRS) were administered to a sample of 142 consumers with severe mental illness. A repeated measurement design with six measurement occasions was used.

Course of recovery and prediction of outcome in young patients in a prolonged vegetative or minimally conscious state after severe brain injury: An exploratory study.

Aims: To explore the course of recovery of consciousness and factors predicting the outcome of severe brain injury with a prolonged period of unconsciousness in children and young adults receiving a specialized rehabilitation treatment, the Early Intensive Neurorehabilitation Programme (EINP).

Methods: A cohort of forty-four patients aged 1.6-25.

Testing hypotheses involving Cronbach's alpha using marginal models.

We discuss the statistical testing of three relevant hypotheses involving Cronbach's alpha: one where alpha equals a particular criterion; a second testing the equality of two alpha coefficients for independent samples; and a third testing the equality of two alpha coefficients for dependent samples. For each of these hypotheses, various statistical tests have been proposed. Over the years, these tests have depended on progressively fewer assumptions.

Mental health recovery: evaluation of a recovery-oriented training program.

Aim: This study investigates the effectiveness of a recovery-oriented training program on knowledge and attitudes of mental health care professionals towards recovery of people with serious mental illness.

Methods: Using data from a longitudinal study of recovery, changes in knowledge and attitudes of 210 mental health care professionals towards recovery were explored using the Recovery Attitude Questionnaire and the Recovery Knowledge Inventory. The study uses a two-group multiple intervention interrupted time-series design which is a variant of the stepped-wedge trial design.

Autonomy-connectedness and internalizing-externalizing personality psychopathology, among outpatients.

Objectives: The aims of this research were to investigate gender differences in levels of autonomy-connectedness, Axis I Psychopathology, and higher order factors of internalizing and externalizing personality psychopathology and, second, to investigate the association between these variables.

Design: The design of this research is cross-sectional and multicentered.

Methods: We used self-report questionnaires, factor analysis, and regression analysis.

The impact of premature childbirth on parental bonding.

The development of an affectionate parent-infant bond is essential for a newborn infant's survival and development. However, from evolutionary theory it can be derived that parental bonding is not an automatic process, but dependent on infants' cues to reproductive potential and parents' access to resources. The purpose of the present study was to examine the process of bonding in a sample of Dutch mothers (n = 200) and fathers (n = 193) of full-term (n = 69), moderately premature (n = 68), and very premature infants (n = 63).

Factor structure of self-reported clinical disorders and personality disorders: a review of the existing literature and a factor analytical study.

Objectives: The aim of this research is to add to the current understanding of the latent factor structure of personality disorders by performing a review of the existing literature (Study 1) and a factor analytical study on the factor structure and the relationship between self-reported Axis I and Axis II psychopathology (Study 2).

Design: The current research (Study 2) is cross-sectional and multicenter.

Results: We found support for the assumption that the borderline personality disorder is a multidimensional construct.

Transfer of the epoxidation of soybean oil from batch to flow chemistry guided by cost and environmental issues.

The simple transfer of established chemical production processes from batch to flow chemistry does not automatically result in more sustainable ones. Detailed process understanding and the motivation to scrutinize known process conditions are necessary factors for success. Although the focus is usually "only" on intensifying transport phenomena to operate under intrinsic kinetics, there is also a large intensification potential in chemistry under harsh conditions and in the specific design of flow processes.

Recent changes in patenting behavior in microprocess technology and its possible use for gas-liquid reactions and the oxidation of glucose.

The miniaturization of continuous processes has been of increasing interest in the past decade, and microreaction technology and flow chemistry have moved from academic and industrial research to commercial applications. With industry taking up such innovations, this trend is also reflected in the patenting behavior of companies active in this area. This review is a continuation of the review paper on microreactor patents published by Hessel et al.

Psychometric properties of three instruments to measure recovery.

Background: The process of recovery is gaining more and more attention within health care for patients with severe mental illness. Therefore, instruments to measure recovery can be useful for clinical and research purposes.

Aims: This study evaluates the psychometric properties of three instruments pertaining to recovery for possible application in the Netherlands.

Comment on "Mantle flow drives the subsidence of oceanic plates".

Adam and Vidal (Reports, 2 April 2010, p. 83) reported sea-floor depth increasing as the square root of distance from the ridge along "mantle flow lines." However, their data actually support a depth-age relationship and "flattening" at older ages.

The multiple propensity score as control for bias in the comparison of more than two treatment arms: an introduction from a case study in mental health.

Background And Objective: The propensity score method (PS) has proven to be an effective tool to reduce bias in nonrandomized studies, especially when the number of (potential) confounders is large and dimensionality problems arise. The PS method introduced by Rosenbaum and Rubin is described in detail for studies with 2 treatment options. Since in clinical practice we are often interested in the comparison of multiple interventions, there was a need to extend the PS method to multiple treatments.

The use of propensity score methods in psychotherapy research. A practical application.

Background: Randomized controlled trials are considered the best scientific proof of effectiveness. There is increasing concern, though, about their feasibility in psychotherapy research. We discuss a quasi-experimental study design for situations in which a randomized controlled trial is not feasible.

Mokken Scale Analysis for Dichotomous Items Using Marginal Models.

Scalability coefficients play an important role in Mokken scale analysis. For a set of items, scalability coefficients have been defined for each pair of items, for each individual item, and for the entire scale. Hypothesis testing with respect to these scalability coefficients has not been fully developed.

Social reactions to adult crying: the help-soliciting function of tears.

The authors investigated how people believe they respond to crying individuals. Participants (N = 530) read 6 vignettes describing situations in which they encountered a person who either cried or did not cry. Participants reported they would give more emotional support to and express less negative affect toward a crying person than a noncrying person.

Predicting individual differences in autonomy-connectedness: the role of body awareness, alexithymia, and assertiveness.

Autonomy-connectedness is the capacity for being on one's own as well as for satisfactorily engaging in interpersonal relationships. Associations have been shown between autonomy-connectedness components (self-awareness, sensitivity to others, and the capacity for managing new situations) and various indices of psychopathology. Both in a theoretical sense as well as for enhancing treatment and prevention, it is relevant to identify which factors most powerfully predict individual differences in autonomy-connectedness: body awareness, alexithymia, or assertiveness.

Personality, psychological stress, and self-reported influenza symptomatology.

Background: Psychological stress and negative mood have been related to increased vulnerability to influenza-like illness (ILI). This prospective study re-evaluated the predictive value of perceived stress for self-reported ILI. We additionally explored the role of the negative affectivity and social inhibition traits.