Differential Myosin 5a splice variants in innervation of pelvic organs.

Myosin proteins interact with filamentous actin and translate the chemical energy generated by ATP hydrolysis into a wide variety of mechanical functions in all cell types. The classic function of conventional myosins is mediation of muscle contraction, but myosins also participate in processes as diverse as exocytosis/endocytosis, membrane remodeling, and cytokinesis. Myosin 5a (Myo5a) is an unconventional motor protein well-suited to the processive transport of diverse molecular cargo within cells and interactions with multiprotein membrane complexes that facilitate exocytosis.

Integrated omics analysis unveils a DNA damage response to neurogenic injury.

Spinal cord injury (SCI) evokes profound bladder dysfunction. Current treatments are limited by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed systemic inosine treatment improved bladder function following SCI in rats.

What is hiding behind the rainbow plot? The gender ideology and LGBTQ+ lobby conspiracies (GILC) scale.

Previous literature on conspiracy beliefs has an important gap, as it has almost completely excluded conspiracy beliefs relating to LGBTQ+ people. The purpose of the present research was to develop and validate a specific tool to measure the Gender Ideology and LGBTQ+ Lobby Conspiracies Beliefs: the GILC scale. Two independent data collections (N  = 1.

Radiation-Induced Oropharyngeal Squamous Cell Carcinoma: Case Report and Review of the Literature.

Background: Radiation therapy (RT) is a mainstay for the treatment of head and neck (HN) cancers, with 80% of patients receiving such treatment. Radiation-induced malignancies represent a life-threatening long-term effect of RT, with an incidence of 0.5% to 15%.

Gay, Lesbian, and Bisexual (LGB) peoples' leadership self-effectiveness: The roles of internalized sexual stigma, LGB positive identity, and traditional masculinity.

Grounded in the theoretical frameworks of the minority stress model and the model of positive identity in sexual minority people, the current research contributes to fill a gap in the previous literature, investigating the relationships among leadership self-effectiveness, internalized sexual stigma, positive identity, and adherence to traditional masculinity of gay, lesbian, and bisexual (LGB) individuals. Through a correlational study ( = 449), we collected data from 229 gay/bisexual men (51%) and 220 lesbian/bisexual women (49%). We hypothesized that lower internalized sexual stigma, higher LGB positive identity, and higher adherence to traditional masculinity were associated to higher self-perceived effectiveness.

Masculinity and Leadership Effectiveness (Self-)Perceptions: The Case of Lesbian Leaders.

In line with the gay glass ceiling effect, sexual minorities are often target of discrimination within work-related contexts, thus potentially undermining their wellbeing at work. For gay men, discrimination may partially be attributed to gay men's stereotypical feminine perception, which does not fit with the stereotypically masculine traits required for leadership positions. Yet, when considering lesbian women, the masculine stereotypical view associated with them may come to represent an advantage in work-related contexts, especially when compared to heterosexual women.

Neuropilin 2 Is a Novel Regulator of Distal Colon Contractility.

Appropriate coordination of smooth muscle contraction and relaxation is essential for normal colonic motility. The impact of perturbed motility ranges from moderate, in conditions such as colitis, to potentially fatal in the case of pseudo-obstruction. The mechanisms underlying aberrant motility and the extent to which they can be targeted pharmacologically are incompletely understood.

Expectations about the "Natural Order of Things" and Conspiracy Beliefs about COVID-19.

The COVID-19 pandemic represents an event that unsettled the social and economic life of many people. When individuals are faced with shocking events, they may need to find plausible explanations for such events to restore control and make sense of reality. The adoption of conspiracy beliefs may represent a functional strategy for this purpose.

Myosin 5a in the Urinary Bladder: Localization, Splice Variant Expression, and Functional Role in Neurotransmission.

Dysregulation of neurotransmission is a feature of several prevalent lower urinary tract conditions, but the mechanisms regulating neurotransmitter release in the bladder are not completely understood. The unconventional motor protein, Myosin 5a, transports neurotransmitter-containing synaptic vesicles along actin fibers towards the varicosity membrane, tethering them at the active zone prior to reception of a nerve impulse. Our previous studies indicated that Myosin 5a is expressed and functionally relevant in the peripheral nerves of visceral organs such as the stomach and the .

An approach to evaluate the quality of radiological reports in Head and Neck cancer loco-regional staging: experience of two Academic Hospitals.

Objectives: To evaluate the quality of the reports of loco-regional staging computed tomography (CT) or magnetic resonance imaging (MRI) in head and neck (H&N) cancer.

Methods: Consecutive reports of staging CT and MRI of all H&N cancer cases from 2018 to 2020 were collected. We created lists of quality indicators for tumor (T) for each district and for node (N).

Conspiracy beliefs of Italian voters for populist parties: The moderated mediational role of political interest and ideological attitudes.

Grounded in the theoretical framework of the dual-process motivational model of ideology and politics, we investigated the mediational role of RWA and SDO on the relationship between voting for populist parties and conspiracy beliefs; the moderation of political interest was also explored. Collapsing different convenience samples gathered after the European election (2014/2015) and the General National Election (2018/2019) allowed us to analyse two datasets (Study 1, n = 4141; Study 2, n = 2301). We hypothesised that populist voters would report higher conspiracy beliefs, RWA, and SDO, compared to non-populist voters and abstainers, and that populist voters would report more conspiracy beliefs through indirect pathways running through RWA and SDO.

Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins.

Botulinum neurotoxins (BoNTs) are the most potent toxins known and are also utilized to treat a wide range of disorders including muscle spasm, overactive bladder, and pain. BoNTs' ability to target neurons determines their specificity, potency, and therapeutic efficacy. Homologous synaptic vesicle membrane proteins synaptotagmin-1 (Syt1) and synaptotagmin-2 (Syt2) have been identified as receptors for BoNT family members including BoNT/B, DC, and G, but their contributions at physiologically relevant toxin concentrations in vivo have yet to be validated and established.

Evaluation of Bi-Layer Silk Fibroin Grafts for Tubular Ureteroplasty in a Porcine Defect Model.

Ureteral reconstruction with autologous tissue grafts is often limited by tissue availability and donor site morbidity. This study investigates the performance of acellular, bi-layer silk fibroin (BLSF) scaffolds in a porcine model of ureteroplasty. Tubular ureteroplasty with BLSF grafts in combination with transient stenting for 8 weeks was performed in adult female, Yucatan, mini-swine ( = 5).

Is Covid-19 a natural event? Covid-19 pandemic and conspiracy beliefs.

In this paper, antecedents and consequences of conspiracy beliefs are investigated in the context of the COVID-19 pandemic in Italy. 618 individuals residing in different geographical area of Italy participated in the study. We found that perceived mortality rate of COVID-19 is positively associated with adherence to conspiracy beliefs and, in turn, with negative outcomes such as: (a) a reduced support for the measures taken to deal with the pandemic emergency, (b) a weaker feeling of guilt for the violation of anti-COVID-19 government rules, and (c) a stronger utilitarian stance which prioritizes economic over health-related outcomes of lockdown.

A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect.

We conducted a preregistered multilaboratory project ( = 36; = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the . Each laboratory implemented one of two procedures that was intended to manipulate self-control and tested performance on a subsequent measure of self-control. Confirmatory tests found a nonsignificant result ( = 0.

Being mindful in the tax context in Italy: Examining whether and how mindfulness relates with tax evasion intentions and support for tax progressivity.

Two studies explored whether and how mindfulness relates with citizens' tax evasion intentions and support for progressive tax rates. Based on theoretical and empirical grounds, in Study 1 (N = 1,175) we proposed that mindfulness would be negatively related with tax evasion intentions through decreased social dominance orientation. Drawing on Duckitt's dual-process motivational model, in Study 2 (N = 722) we proposed that mindfulness would be positively related with support for progressive taxation through the mediation of lower competitive-jungle beliefs, and then lower social dominance orientation.

Effectiveness and Safety of A Nutraceutical Formulation for the Treatment of Functional Dyspepsia in Primary Care.

Background: Although FD may affect up to 10% of the general population, the therapy for FD is not standard. Recently, ginger-based food supplements have been proposed in order to restore FD symptoms. Our aim was to assess the efficacy of a new nutraceutical formulation containing extract of gingerol and thymus as a possible natural treatment in managing the symptoms of functional dyspepsia (FD).

A Multilab Replication of the Ego Depletion Effect.

There is an active debate regarding whether the ego depletion effect is real. A recent preregistered experiment with the Stroop task as the depleting task and the antisaccade task as the outcome task found a medium-level effect size. In the current research, we conducted a preregistered multilab replication of that experiment.

Expression of Myosin 5a splice variants in murine stomach.

Background: The motor protein, Myosin 5a (Myo5a) is known to play a role in inhibitory neurotransmission in gastric fundus. However, there is no information regarding the relative expression of total Myo5a, or of its alternative exon splice variants, across the stomach. This study investigated the differential distribution of Myo5a variants expressed within distinct anatomical regions of murine stomach.

Can moral convictions against gender inequality overpower system justification effects? Examining the interaction between moral conviction and system justification.

It has been shown that disadvantaged groups who endorse system-justifying beliefs tend to internalize their state of inferiority by expressing ingroup derogation and opposing collective action for change. In the present research, we recruited women - as disadvantaged group - from different countries (the United States, the United Kingdom, Italy) and examined whether their moral conviction against gender inequality, as an absolute stance that does not tolerate any violation, may interact with and overpower system-justifying beliefs. Results from three studies provided support for our hypotheses.

Embrace the leadership challenge: The role of Gay men's internalized sexual stigma on the evaluation of others' leadership and one's own.

Grounded in the framework of the gay glass ceiling, the current research investigated the effect of gay men's internalized sexual stigma (ISS) on both the perceived effectiveness of other gay men's leadership and on their self-perceived leadership effectiveness and their intention to apply to a leadership position. In three studies (N = 402), we manipulated either the leader's sexual orientation (SO) (study 1), or his adherence to traditional gender roles (TGR) (study 2), or participants' fictitious masculinity score (study 3). Our hypotheses were as follows: the leader's SO and TGR would moderate the association of gay participants' ISS with their positive attitudes towards the leader and with his leadership effectiveness; and gay participants' masculinity threat would moderate the association of their ISS with their intention to apply to a leadership position, and with their self-perceived effectiveness as potential leaders.

Diagnosis of SARS-CoV-2 by RT-PCR Using Different Sample Sources: Review of the Literature.

Objective: The most widely used diagnostic technique for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is real-time reverse transcriptase-polymerase chain reaction (RT-PCR). It can be done on different samples: nasopharyngeal swabs (NPS) or oropharyngeal swabs (OPS), and self-collected saliva. However, negative findings do not rule out infection.