Publications by authors named "Cristofaro E"
Article Synopsis
- Endometriosis and inflammatory bowel disease (IBD) share similarities in symptoms and may be difficult to differentiate, prompting a review of their relationship based on existing research.
- * Despite limited studies, some evidence indicates a possible increased risk of IBD in women with endometriosis, with chronic symptoms overlapping between the two conditions.
- * A multidisciplinary approach involving both gastroenterologists and gynecologists is recommended to ensure accurate diagnosis and treatment for patients exhibiting symptoms of either condition.*
Article Synopsis
- In patients with inflammatory bowel disease (IBD), interleukin-34 (IL-34) activates harmful signaling pathways, but the triggers for its production are not well-understood.
- The study found that bromodomain-containing 4 (BRD4) is over-expressed in IBD and may enhance IL-34 production, with both proteins showing increased levels and co-localization in inflammatory cells.
- Experiments demonstrated that inhibiting BRD4 led to reduced IL-34 expression, suggesting that BRD4 plays a key role in regulating IL-34 and contributing to inflammation in IBD.
A rare case of squamous cell carcinoma originating from esophageal papilloma.
United European Gastroenterol J
November 2024
Background And Aim: Post-colonoscopy colorectal cancer [PCCRC] is a colorectal cancer [CRC] diagnosed after a colonoscopy in which no cancer was detected [index colonoscopy]. Although the overall cumulative rates of PCCRC are low in both the general population and inflammatory bowel disease [IBD] patients, the overall incidence of PCCRC in IBD is greater than that documented in the general population. This study aimed to identify the index colonoscopy-related factors and patients' characteristics influencing IBD-associated PCCRC development.
View Article and Find Full Text PDFIn recent years, therapeutic endoscopy has become a fundamental tool in the management of gallbladder diseases in light of its minimal invasiveness, high clinical efficacy, and good safety profile. Both endoscopic transpapillary gallbladder drainage (TGBD) and endoscopic ultrasound (EUS)-guided gallbladder drainage (EUS-GBD) provide effective internal drainage in patients with acute cholecystitis unfit for cholecystectomy, avoiding the drawbacks of external percutaneous gallbladder drainage (PGBD). The availability of dedicated lumen-apposing metal stents (LAMS) for EUS-guided transluminal interventions contributed to the expansion of endoscopic therapies for acute cholecystitis, making endoscopic gallbladder drainage easier, faster, and hence more widely available.
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- * Current and developing small molecules for UC, including Janus kinase (JAK) inhibitors and sphingosine-1-phosphate receptor (S1Pr) inhibitors, show promise, especially in terms of safety and potential for clinical remission, based on recent trials.
- * Despite some successes with small molecules, such as the positive effects of S1Pr inhibitor Etrasimod, many patients still require more effective treatment options to achieve better disease control outcomes.
Background And Aims: Traction has become the reference strategy for colorectal endoscopic submucosal dissection (ESD). One of its major limitations is that the force of traction decreases as dissection progresses. The ATRACT traction device (ATRACT Device and Co, Lyon, France) uses a pulley system to increase traction during the procedure, making it easier and faster.
View Article and Find Full Text PDFNecrotizing pancreatitis is a complex clinical condition burdened with significant morbidity and mortality. In recent years, the huge progress of interventional endoscopic ultrasound (EUS) has allowed a shift in the management of pancreatic necrotic collections from surgical/percutaneous approaches to mini-invasive endoscopic internal drainage and debridement procedures. The development of lumen-apposing metal stents (LAMSs), devices specifically dedicated to transmural EUS interventions, further prompted the diffusion of such techniques.
View Article and Find Full Text PDFAims: Point-of-care ultrasound (POCUS) is the acquisition and interpretation of ultrasound imaging at the bedside to solve specific clinical questions based on signs and symptoms of presentation. While several studies evaluated POCUS diagnostic accuracy for a variety of clinical pictures in the emergency department (ED), only a few data are available on POCUS diagnostic accuracy performed by physicians with different POCUS skills. The objective of this research was to evaluate the diagnostic accuracy of POCUS compared to standard diagnostic imaging in the ED.
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