In Vitro and in Vivo Study of Poly(Lactic⁻co⁻Glycolic) (PLGA) Membranes Treated with Oxygen Plasma and Coated with Nanostructured Hydroxyapatite Ultrathin Films for Guided Bone Regeneration Processes.

Unlabelled: The novelty of this study is the addition of an ultrathin layer of nanostructured hydroxyapatite (HA) on oxygen plasma modified poly(lactic⁻⁻glycolic) (PLGA) membranes (PO₂) in order to evaluate the efficiency of this novel material in bone regeneration.

Methods: Two groups of regenerative membranes were prepared: PLGA (control) and PLGA/PO₂/HA (experimental). These membranes were subjected to cell cultures and then used to cover bone defects prepared on the skulls of eight experimental rabbits.