Publications by authors named "Cristobal Moreno"
Article Synopsis
- New surgery techniques like E-POEM, G-POEM, and Z-POEM are minimally invasive methods that help people with swallowing problems.
- A study looked at 119 patients in the Middle East and North Africa to see if these surgeries are safe and effective, showing that they worked well for most people.
- There were some minor complications, but overall, these surgeries had low risks, and the results in this area are similar to studies from other parts of the world.
Understanding the signaling cascades that govern adipocyte metabolism and differentiation is necessary for the development of therapies for obesity. Toll-like receptors (TLRs) are key mediators in adipogenesis, but their specific role is not completely understood. In this study, siRNA knockdown of in 3T3-L1 cells allowed them to differentiate more efficiently into adipocytes, whereas the opposite was observed for the knockdown of .
View Article and Find Full Text PDFAims/hypothesis: In mammals, the evolutionary conserved family of Mg(2+)-dependent phosphatidate phosphatases (PAP1), involved in phospholipid and triacylglycerol synthesis, consists of lipin-1, lipin-2 and lipin-3. While mutations in the murine Lpin1 gene cause lipodystrophy and its knockdown in mouse 3T3-L1 cells impairs adipogenesis, deleterious mutations of human LPIN1 do not affect adipose tissue distribution. However, reduced LPIN1 and PAP1 activity has been described in participants with type 2 diabetes.
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