Publications by authors named "Cristobal Frutos"

The eighth workshop of the Worldwide Network for Blood and Marrow Transplantation (WBMT) was held in Islamabad, Pakistan, from September 22 to 23, 2022, aiming to foster hematopoietic stem cell transplant (HSCT) activity in the World Health Organization (WHO) Eastern Mediterranean Region (EMRO). Participating countries, including Pakistan, Oman, Iran, and Saudi Arabia, reported increased HSCT in the last few years, whereas others from the EMRO and beyond, including Qatar, United Arab Emirates, Nepal, and Bangladesh, started HSCT recently and have developed HSCT programs with excellent results. During educational sessions and open dialog, participating teams and international experts from the WBMT shared their experience and discussed minimum essential requirements for establishing and expanding HSCT in emerging countries, indications for HSCT training and dissemination of knowledge, stem cell donor selection and safety, quality assurance in transplant centers, and the value and importance of transplant outcome databases.

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  • Hematopoietic cell transplantation (HCT) is crucial for treating blood-related diseases, but Latin America faces challenges in access due to limited training programs for HCT professionals.
  • A study by the Latin-American Bone Marrow Transplantation Group surveyed 127 HCT centers across 14 countries to analyze the state of training programs, revealing that only 39% of centers responded and most programs are lacking in quality and resources.
  • Major barriers identified included insufficient funding, few transplant procedures, and a lack of qualified instructors, with proposed solutions focusing on increasing student mobility, enhancing program quality, and improving funding access.
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  • * Both types of HCT are risky and complicated, but global collaboration among medical professionals has established it as a standard treatment for many serious blood-related illnesses, resulting in improved patient outcomes.
  • * Over 1.5 million HCT procedures were performed from 1957 to 2019, and this number continues to rise globally, supported by registries and international medical societies.
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Promoting access to and excellence in hematopoietic cell transplantation (HCT) by collecting and disseminating data on global HCT activities is one of the principal activities of the Worldwide Network for Blood and Marrow Transplantation, a non-governmental organization in working relations with the World Health Organization. HCT activities are recorded annually by member societies, national registries and individual centers including indication, donor type (allogeneic/autologous), donor match and stem cell source (bone marrow/peripheral blood stem cells/cord blood). In 2018, 1,768 HCT teams in 89 countries (6 World Health Organization regions) reported 93,105 (48,680 autologous and 44,425 allogeneic) HCT.

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  • * Between 2009 and 2016, global HSCT use for AML rose significantly, particularly in resource-limited regions, with an overall 54.9% increase, although access remains heavily skewed towards high-resource areas.
  • * Utilization rates vary widely by region, with younger patients (<70 years) experiencing even more disparities; AMR-N showed the highest rates of HSCT, while AFR/EMR and AMR-S lagged far behind.
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A total of 5642 hematopoietic cell transplants (HCT) in 5445 patients (2196-40% allogeneic and 3249-60% autologous) were reported by 127 teams in 14 Latin American countries that answered the 2018 LABMT/WBMT Global Transplant Activity survey. The transplant rate (defined as the number of first transplants per 10 million inhabitants per year) was 85 (51 autologous and 34 allogeneic) in 2018. The main indications for allogeneic HCT were acute leukemias (60%), while plasma cell disorders and lymphomas were the most common conditions warranting autologous HCT (50 and 36%, respectively).

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The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.

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Article Synopsis
  • Hematopoietic cell transplants are complicated and expensive, putting a lot of pressure on healthcare systems, especially in poorer countries.
  • In 2017, over 4,500 transplants were done in 13 Latin American countries, but rates varied greatly, ranging from 345 in Uruguay to only 12 in Venezuela.
  • Higher transplant costs and procedures done in private hospitals with government funding were linked to more transplants, while lower costs and public hospitals usually meant fewer transplants.
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