Publications by authors named "Cristinel D Badiu"
Anti-epidermal growth factor receptor (EGFR)-targeted therapy has been intensely researched in the last years, motivated by the favorable results obtained with monoclonal antibodies in HER2-enriched breast cancer (BC) patients. Most researched alternatives of anti-EGFR agents were tyrosine kinase inhibitors (TKIs) and monoclonal antibodies. However, excluding monoclonal antibodies trastuzumab and pertuzumab, the remaining anti-EGFR molecules have exhibited disappointing results, due to the lack of specificity and frequent adverse side effects.
View Article and Find Full Text PDFSuspicion of lead poisoning is confirmed by its concentration in blood and protoporphyrin red blood cells. At low concentrations, lead influences the synthesis of the heme in the sense of lowering it. Acute and chronic lead intoxication is extremely polymorphic in regards to its clinical manifestations, with digestive, hematological, cardiovascular, renal hepatic and neurological features.
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- The study compared the clinical outcomes and complications of diabetic and non-diabetic patients undergoing emergency cholecystectomy for acute cholecystitis over two years.
- A total of 46 diabetic patients and 287 non-diabetic patients were analyzed for various factors, including comorbidities, biological variables, and postoperative complications.
- Although diabetes did not significantly affect the severity of cholecystitis or surgery conversion risk, diabetic patients experienced more postoperative complications, emphasizing the need for careful perioperative management and glycemic control.
The present study investigated the effects of the COVID-19 pandemic on the clinical presentation and therapeutic management of acute surgical abdomen. A retrospective study of emergency hospitalizations with a diagnosis of acute surgical abdomen between April and July 2020 vs. a similar period in 2019 was performed.
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- The study examines how age affects safety and outcomes of laparoscopic cholecystectomy for acute cholecystitis, analyzing data from 333 patients over two years.
- These patients were categorized into four age groups, with older age linked to higher severity, complications, and increased conversion to open surgery.
- Laparoscopic cholecystectomy showed better outcomes in terms of complications and hospital stay compared to open surgery, especially when considering systemic inflammation and specific comorbidities like diabetes in elderly patients.
This review discusses the evidence on diabetic retinopathy (DR) in patients with diabetic foot ulceration (DFU). A systematic literature review was performed on PubMed, Medline, Springer Nature, and Scopus, following the PRISMA guidelines, using the following terms, individually or in combination: "diabetic foot ulcer" OR "diabetic foot syndrome" OR "DFU" and "diabetic retinopathy." The initial search yielded 648 articles published between 1975 and 2020.
View Article and Find Full Text PDFNowadays, surgical innovations incorporate new technological conquests and must be validated by evidence-based medicine. The use of augmented reality-assisted indocyanine green (ICG) fluorescence has generated a myriad of intraoperative applications such as demonstration of key anatomical landmarks, sentinel lymph nodes, and real-time assessment of local blood flow. This paper presents a systematic review of the clinical evidence regarding the applications of ICG near-infrared (NIR) fluorescence in colorectal surgery.
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- - Ogilvie syndrome, or acute colonic pseudo-obstruction (ACPO), involves significant dilation of the large bowel without any mechanical blockage, primarily affecting patients in intensive care with severe underlying conditions.
- - The exact cause of ACPO is not fully understood, but it's believed that disturbances in the autonomic nervous system can impair the colon's motor function.
- - Early detection and treatment are crucial to prevent serious complications like ischemia or perforation, and the study aims to provide insights into effective management strategies for critically ill patients at risk of developing this condition.
Article Synopsis
- Burnout is a critical issue for resident doctors, particularly heightened during the COVID-19 pandemic due to increased stress and workload.
- The article reviews literature on burnout in medical residents and explains its prevalence across different specialties, revealing that some are at higher risk.
- It also discusses a study conducted in a non-Covid emergency hospital in Romania, exploring the impact of burnout and suggesting potential solutions to alleviate this growing concern.
Patients with spinal cord injury (SCI) with neurogenic bladder (NB) represent a major medical problem, which initiated the search for a non-invasive and effective treatment that is easy to apply and without side effects. A study was performed using interferential medium frequency current electrical stimulation (IMFC ES) on 332 patients shortly after SCI diagnosed with NB dysfunction. All subjects received standard care and patients of the experimental group additionally received IMFC ES.
View Article and Find Full Text PDFIntroduction: Metastatic diseases are seen in approximately 25% of all cases with renal cell carcinoma and sometimes they can appear in unusual sites.
Case Presentation: We present a 35-year old patient with a painful left axillary mass which causes the functional impairment of the left arm. The axillary mass appeared 2 years after the nephrectomy performed for a left renal cell carcinoma.
Periampullary duodenal diverticula are associated with the presence of common bile duct stones, being encountered more frequently with the increase of age. We present the case of a 76 years old female patient, who underwents emergency surgery for a perforated lithiasic gangrenous acute cholecystitis and for whom we perform a cholecystectomy and an external biliary drainage using a transcystic tube. Both preoperative and postoperative imaging and endoscopic examinations certify the presence of a periampullary duodenal diverticulum.
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