Exploring the Limits of Cyanobactin Macrocyclase PatGmac: Cyclization of PawS-Derived Peptide Sunflower Trypsin Inhibitor-1 and Cyclotide Kalata B1.

The subtilisin-like macrocyclase PatGmac is produced by the marine cyanobacterium . This enzyme is involved in the last step of the biosynthesis of patellamides, a cyanobactin type of ribosomally expressed and post-translationally modified cyclic peptides. PatGmac recognizes, cleaves, and cyclizes precursor peptides after a specific recognition motif comprised of a C-terminal tail with the sequence motif -AYDG.

Paenidigyamycin A, Potent Antiparasitic Imidazole Alkaloid from the Ghanaian sp. DE2SH.

A new alkaloid paenidigyamycin A () was obtained from the novel Ghanaian sp. isolated from the mangrove rhizosphere soils of the tree growing in the wetlands of the Digya National Park, Ghana. Compound was isolated on HPLC at t = 37.