Publications by authors named "Cristina Sotomayor Vivas"
Article Synopsis
- Different tumors with the same diagnosis can act differently in response to treatments because they can have unique genetic features.
- Scientists studied a large number of breast cancer cases and found that certain inherited traits from parents may help explain why some tumors grow or change in different ways.
- Tumors that manage to survive the immune system's attacks are often more aggressive and less responsive to treatment, but understanding these genetic differences can help doctors target better treatments.
The amazing complexity of gene regulatory circuits, and biological systems in general, makes mathematical modeling an essential tool to frame and develop our understanding of their properties. Here, we present some fundamental considerations to develop and analyze a model of a gene regulatory circuit of interest, either representing a natural, synthetic, or theoretical system. A mathematical model allows us to effectively evaluate the logical implications of our hypotheses.
View Article and Find Full Text PDFThe function of a protein is strongly dependent on its structure. During evolution, proteins acquire new functions through mutations in the amino-acid sequence. Given the advance in deep mutational scanning, recent findings have found functional change to be position dependent, notwithstanding the chemical properties of mutant and mutated amino acids.
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