Publications by authors named "Cristina S Catana"
The HLA profile is essential in cell and tissue transplantation, particularly in patients with autoimmune conditions and infections. Due to the extreme polymorphism in certain HLA loci, it also serves as a key tool for population genetic analysis. This study aimed to identify the allele and haplotype distributions of HLA class I (A, B, and C) and class II (DRB1) genotypes in unrelated hematopoietic stem cell donors.
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- The study investigates the potential role of specific variants of human leukocyte antigens (HLA) and microRNAs (miRNAs) in determining risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- A systematic review and meta-analysis were performed using international databases to assess how these genetic factors contribute to cognitive decline and their potential as early biomarkers for AD.
- Results indicated that certain HLA variants are linked to increased risk for cognitive decline while others provide protection, with let-7 and miR-15/16 identified as promising miRNA biomarkers for early detection of AD.
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- The study investigated the link between human leukocyte antigen (HLA) genes and end-stage renal disease (ESRD) in 2392 patients awaiting kidney transplants, highlighting genetic and environmental influences.
- Results showed that certain HLA alleles, such as HLA-A*11 and HLA-B*41, were positively associated with an increased risk of ESRD, while others like HLA-DRB1*07 provided a protective effect.
- The findings suggest that understanding HLA polymorphisms could help identify patients at higher risk for ESRD and improve outcomes post-transplant by enhancing graft survival.
Background And Aims: Current nonalcoholic fatty liver disease (NAFLD) guidelines do not provide any recommendations regarding the waist-to-height ratio (WHtR), a simple obesity metric calculated by dividing waist circumference by height. Therefore, we performed a systematic review and meta-analysis aiming to evaluate WHtR in NAFLD.
Methods: We performed a systematic electronic search on PubMed, Embase, and Scopus, identifying observational studies assessing WHtR in NAFLD.
Chronic inflammation is demonstrated to play a direct role in carcinogenesis. Our exploratory study aimed to assess the potential added value of two inflammation biomarkers, chitotriosidase and neopterin, in follow-up evaluation of patients with colorectal cancer (CRC). An observational exploratory study was conducted.
View Article and Find Full Text PDFThe chronic complications of diabetes mellitus (DM) are accompanied by inflammatory manifestations. Our study aimed to evaluate a possible association between the inflammatory status (reflected by serum chitotriosidase and neopterin) and the timely evolution and occurrence of chronic microvascular complications in patients with type 1 DM. This observational, cross-sectional study included 82 type 1 DM patients from the Centre for Diabetes, Nutrition and Metabolic Diseases, Cluj-Napoca, Romania.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Current treatment options for inoperable HCCs have decreased therapeutic efficacy and are associated with systemic toxicity and chemoresistance. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent enzyme that is frequently overexpressed in HCC, where it promotes tumorigenicity, metastasis, and chemoresistance.
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- The study aimed to create two cost-effective rat models of inflammatory bowel diseases (IBD) using dextran sodium sulfate (DSS) and 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) to better understand the diseases.
- Researchers assessed the impact of these compounds on oxidative stress, particularly looking at glutathione peroxidase (GPx) activity, and compared the resulting histological changes in the rats' colons.
- Both models produced characteristics similar to human conditions, showing that DSS and TNBS can be reliable for studying acute inflammation in IBD.
In a continuous and mutual exchange of information, cancer cells are invariably exposed to microenvironment transformation. This continuous alteration of the genetic, molecular and cellular peritumoral stroma background has become as critical as the management of primary tumor progression events in cancer cells. The communication between stroma and tumor cells within the extracellular matrix is one of the triggers in colon and liver carcinogenesis.
View Article and Find Full Text PDFInflamma-miRs in Aging and Breast Cancer: Are They Reliable Players?
Front Med (Lausanne)
December 2015
Human aging is characterized by chronic low-grade inflammation known as "inflammaging." Persistent low-level inflammation also plays a key role in all stages of breast cancer since "inflammaging" is the potential link between cancer and aging through NF-kB pathways highly influenced by specific miRs. Micro-RNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at a posttranscriptional level.
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