Publications by authors named "Cristina Romero-Aranda"
MicroPubl Biol
November 2024
Article Synopsis
- - The Integrator complex consists of at least 13 conserved proteins that interact with RNA polymerase II to regulate snRNA processing and gene expression.
- - This study highlights the role of Integrator subunit 6 (INTS-6) in the DNA damage response, specifically its necessity for forming RAD-51 foci after X-ray radiation exposure.
- - The presence of INTS-6 is also shown to be essential for the phosphorylation of CDK-1 at Tyr-15, contributing to our understanding of how the Integrator complex participates in DNA repair processes.
Cancers (Basel)
June 2024
Article Synopsis
- The human Integrator complex, comprising 15 subunits, is crucial for processing small nuclear RNAs and splicing messenger RNAs, while also regulating RNA polymerase II activity at gene promoters in response to growth factors.
- Mutations in a specific subunit of the Integrator complex are linked to various tumors, particularly colorectal cancer, where deregulation is observed in 8.3% of cases from a study in La Rioja, Spain.
- The study suggests that poor function of the Integrator complex, indicated by elevated unprocessed snRNA levels, is a negative prognostic biomarker for colorectal cancer, and highlights how early screening and molecular profiling can enhance patient survival rates.
Article Synopsis
- 4D microscopy is a crucial technique for studying embryonic development in animals, particularly using the transparent nematode Caenorhabditis elegans as a model organism.
- The article outlines a detailed protocol for growing C. elegans, preparing embryos, and utilizing 4D DIC microscopy combined with specialized software for cell lineage tracing.
- This approach allows researchers to observe and analyze embryonic dynamics and detect defects in cellular processes like spindle orientation and cell migration, providing a comprehensive understanding of development at the cellular level.
