Publications by authors named "Cristina Mota"
Purpose: Portal vein thrombosis (PVT) remains a significant clinical challenge with limited treatment options, particularly in patients at high risk of hemorrhage or intestinal infarction. In such cases, mechanical thrombectomy (MT) and catheter-directed thrombolysis (CDT), either as alternative treatments or in combination with systemic anticoagulation, may provide a more suitable approach.
Case Report: Here, we present 3 cases of symptomatic acute/subacute PVT with concurrent mesenteric vein thrombosis, in which patients underwent MT and CDT.
Article Synopsis
- Cognitive dysfunction in multiple sclerosis (MS) is common and challenging to treat, prompting investigation into potential therapies like dimethyl fumarate.
- In a mouse model of MS, treatment with dimethyl fumarate improved spatial memory performance without causing structural damage to the hippocampus, indicating its neuroprotective effects.
- The improvement in memory was linked to reduced demyelination in the fimbria, a key pathway for hippocampal function, suggesting that dimethyl fumarate can positively impact memory even when treatment starts after significant symptoms like hindlimb paralysis develop.
Aging is associated with cognitive decline. Herein, we studied a large cohort of old age and young adult male rats and confirmed that, as a group, old rats display poorer spatial learning and behavioral flexibility than younger adults. Surprisingly, when animals were clustered as good and bad performers, our data revealed that while in younger animals better cognitive performance was associated with longer dendritic trees and increased levels of synaptic markers in the hippocampus and prefrontal cortex, the opposite was found in the older group, in which better performance was associated with shorter dendrites and lower levels of synaptic markers.
View Article and Find Full Text PDFThe exposure to high glucocorticoids (GC) triggers neuronal atrophy and cognitive deficits, but the exact cellular mechanisms underlying the GC-associated dendritic remodeling and spine loss are still poorly understood. Previous studies have implicated sustained GC elevations in neurodegenerative mechanisms through GC-evoked hyperphosphorylation of the cytoskeletal protein Tau while Tau mislocation has recently been proposed as relevant in Alzheimer's disease (AD) pathology. In light of the dual cytoplasmic and synaptic role of Tau, this study monitored the impact of prolonged GC treatment on Tau intracellular localization and its phosphorylation status in different cellular compartments.
View Article and Find Full Text PDFCow raw milk from dairy cooperatives was examined for its microbial composition. Among the isolates identified, 17.6% were yeasts.
View Article and Find Full Text PDF