False Negative Inferior Petrosal Sinus Sampling in Young-Onset Cushing Disease: What Happens Next.

Introduction: False negative results during inferior petrosal sinus sampling (IPSS) may complicate the diagnostic evaluation of patients with ACTH-dependent Cushing syndrome (CS). The management of these patients can be confusing for clinicians and lead to delayed management.

Methods: We studied patients with young-onset (<21yo) CD who underwent IPSS during their diagnostic evaluation.