Publications by authors named "Cristina Marin-Garcia"
Article Synopsis
- * The study employed cytological analysis and genetic methods to assess how chromosomal fusions affect recombination patterns, revealing that these fusions lead to changes like increased recombination near chromosome ends and altered interference levels in crossover events.
- * The findings highlight the combined influence of Robertsonian fusions and the Prdm9 gene on genomic recombination, with Prdm9 playing a key role at the population level, while the effects of fusions were more localized to specific chromosome regions.
Chromosome folding has profound impacts on gene regulation, whose evolutionary consequences are far from being understood. Here we explore the relationship between 3D chromatin remodelling in mouse germ cells and evolutionary changes in genome structure. Using a comprehensive integrative computational analysis, we (i) reconstruct seven ancestral rodent genomes analysing whole-genome sequences of 14 species representatives of the major phylogroups, (ii) detect lineage-specific chromosome rearrangements and (iii) identify the dynamics of the structural and epigenetic properties of evolutionary breakpoint regions (EBRs) throughout mouse spermatogenesis.
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