Effects of the olive, extra virgin olive and canola oils on cisplatin-induced clastogenesis in Wistar rats.

Cisplatin is one of the mostly used antineoplastic drugs in the treatment of cancer, but its clastogenic potential has become of great interest. In patients treated with long-term cisplatin, genetic damage can be observed during chemotherapy or many years later. The aim of this study was to investigate the possible anticlastogenic effect of pretreatment with olive, extra virgin olive, canola or corn oils on cisplatin-induced chromosomal aberrations in Wistar rat bone marrow cells.