Comparative chemical genomics in species identifies the alkaline phosphatase phoD as a novel determinant of resistance.

Unlabelled: is an emerging zoonosis and widely distributed veterinary infection caused by 100+ species of parasites. The diversity of parasites, coupled with the lack of potent inhibitors necessitates the discovery of novel conserved druggable targets for the generation of broadly effective antibabesials. Here, we describe a comparative chemogenomics (CCG) pipeline for the identification of novel and conserved targets.