The Ca channel TRPV4 is dispensable for Ca influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines.

Cell swelling as a result of hypotonic stress is counteracted in mammalian cells by a process called regulatory volume decrease (RVD). We have recently discovered that RVD of human keratinocytes requires the LRRC8 volume-regulated anion channel (VRAC) and that Ca exerts a modulatory function on RVD. However, the ion channel that is responsible for Ca influx remains unknown.