Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury.

Unlabelled: Noncoding RNAs (ncRNAs) are increasingly recognized as bioactive. Here we report the development of TY1, a synthetic ncRNA bioinspired by a naturally-occurring human small Y RNA with immunomodulatory properties. TY1 upregulates TREX1, an exonuclease that rapidly degrades cytosolic DNA.