Publications by authors named "Cristina Grande-Aragon"
Article Synopsis
- GPIHBP1 is crucial for lipoprotein lipase (LPL) function, which helps break down triglycerides in the bloodstream, and mutations in GPIHBP1 can lead to type I hyperlipoproteinemia.
- Two unrelated patients with severe hypertriglyceridemia and pancreatitis were studied, revealing very low LPL activity without LPL gene mutations or ApoCII deficiency.
- The study identified two new mutations in the GPIHBP1 gene in these patients, confirming its role in their severe hypertriglyceridemia.
Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-15 (IL-15) in cancer patients with cachexia at diagnosis of malignancy and 8 weeks later.
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