D-dimer to rule out venous thromboembolism during pregnancy: A systematic review and meta-analysis.

Background: The usefulness of D-dimer measurement to rule out venous thromboembolism (VTE) during pregnancy is debated.

Objectives: We performed a systematic review and meta-analysis to investigate the safety of D-dimer to rule out acute VTE in pregnant women with suspected pulmonary embolism and/or deep vein thrombosis.

Methods: Two reviewers independently identified studies through PubMed and Embase until June 2021, week 1.

Optimal Management of Cirrhotic Ascites: A Review for Internal Medicine Physicians.

Clinical history of liver cirrhosis is characterised by two phases: the asymptomatic phase, also termed 'compensated cirrhosis', and the phase of complications due to the development of portal hypertension and liver dysfunction, also termed 'decompensated cirrhosis', in which patients may develop ascites, the most frequent and clinically relevant complication of liver cirrhosis. Ascites can be classified into uncomplicated and complicated according to the development of refractoriness, spontaneous bacterial peritonitis (SBP) or the association with hepatorenal syndrome (HRS). In this narrative review, we will extensively discuss the optimal pharmacological and non-pharmacological management of cirrhotic ascites with the aim to offer an updated practical guide to Internal Medicine physicians.