Publications by authors named "Cristina Daniela Kelemen"
Article Synopsis
- Venetoclax (VEN) shows promising activity against various lymphomas and leukemias, but remissions tend to be short, prompting the need for combination therapies.
- Research found that combining VEN with A1155463, a BCL-XL inhibitor, created a strong synergistic effect and could overcome resistance in certain cell lines, even those lacking BCL2L11/BIM, which is often linked to VEN resistance.
- In vivo studies confirmed the effectiveness of this combination in multiple patient-derived models, and a unique treatment schedule of 4 days on/3 days off minimized side effects, making this a potential innovative approach for treating BCL2+ hematologic malignancies.
Article Synopsis
- Bcl-2 family proteins, particularly Bax and Bak, are known for regulating apoptosis but also exhibit less understood activities unrelated to cell death.
- Research on Bax/Bak-deficient human cancer cells revealed that U87 glioblastoma cells showed enhanced respiratory function and faster proliferation, while HBL-2 B lymphoma cells experienced slight respiratory suppression.
- The study indicates that the regulation of mitochondrial transcription elongation factor TEFM in Bax/Bak-deficient cells affects mitochondrial respiratory complex subunits, influencing metabolism and cell proliferation.
