Publications by authors named "Cristina Castro Alonso"
Background: Patients with non-functioning renal grafts constitute approximately 4% of patients with incident dialysis. Complete withdrawal of immunosuppression has been associated with a higher risk of HLA sensitization and renal graft intolerance syndrome (GIS).
Methods: We conducted a retrospective observational study of 63 patients with renal graft failure (from January 2012 to December 2022).
Article Synopsis
- Chronic kidney disease of unknown etiology (CKDUE) is a leading global cause of kidney failure, and the GENSEN Study aimed to explore its genetic causes through extensive genetic testing on a large patient population.
- The study involved 818 patients under 45 with advanced CKDUE, discovering pathogenic gene variants in about 25% of them, with type IV collagen genes being the most commonly affected.
- The research revealed significant previously undiagnosed genetic kidney diseases, suggesting that genomic testing can be a valuable approach in understanding and treating CKDUE.
Fracture risk assessment in patients with chronic kidney disease (CKD) has been included in the CKD-MBD ("Chronic Kidney Disease-Mineral and Bone Disorders") complex in international and national nephrology guidelines, suggesting for the first time the assessment of bone mineral density (BMD) if the results can influence therapeutic decision-making. However, there is very little information on actual clinical practice in this population. The main objective of the ERCOS (ERC-Osteoporosis) study is to describe the profile of patients with CKD G3-5D with osteoporosis (OP) and/or fragility fractures treated in specialized nephrology, rheumatology and internal medicine clinics in Spain.
View Article and Find Full Text PDFData suggest that non-calcium-based binders, and specifically sevelamer, may lead to lower rates of death when compared with calcium-based binders in end-stage renal disease (ESRD) patients. However, the association between sevelamer use and mortality for those with non-dialysis-dependent chronic kidney disease (NDD-CKD) patients has been uncertain. Our research is presented in a prospective cohort study.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the clinical features of autosomal dominant polycystic kidney disease (ADPKD) in young adults aged 18-30, highlighting their morbidity despite the disease typically appearing in adulthood.
- In a cohort of 346 young adults, the average age of hypertension diagnosis was just over 21, with a prevalence of 28%, which increased with age.
- The findings suggest that young adults with ADPKD experience significant health issues, underscoring the importance of early detection and management of hypertension in this group.
Article Synopsis
- The study investigates the prevalence of vertebral fractures (VF) in patients with non-dialysis dependent chronic kidney disease (NDD-CKD) and their relationship with mortality and bone metabolism.
- Among 612 patients, VF were found in 18% and several clinical factors, like serum phosphate levels and bisphosphonate treatment, were linked to the likelihood of having VF.
- Over a 35-month follow-up, about 10% of the participants died, with VF identified as an independent predictor of mortality even after accounting for other health factors.
Osteoporosis (OP) and chronic kidney disease (CKD) both independently affect bone health. A significant number of patients with CKD have decreased bone mineral density (BMD), are at high risk of fragility fractures and have an increased morbidity and mortality risk. With an ageing population, these observations are not only dependent on "renal osteodystrophy" but also on the associated OP.
View Article and Find Full Text PDFOsteoporosis (OP) and chronic kidney disease (CKD) independently influence bone and cardiovascular health. A considerable number of patients with CKD, especially those with stages 3a to 5D, have a significantly reduced bone mineral density leading to a high risk of fracture and a significant increase in associated morbidity and mortality. Independently of classic OP related to age and/or gender, the mechanical properties of bone are also affected by inherent risk factors for CKD ("uraemic OP").
View Article and Find Full Text PDFBackground: Compared with conventional haemodialysis (HD), online haemodiafiltration (OL-HDF) achieves a more efficient removal of uraemic toxins and reduces inflammation, which could favourably affect nutritional status. We evaluate the effect of OL-HDF on body composition and nutritional status in prevalent high-flux HD (HF-HD) patients.
Methods: In all, 33 adults with chronic kidney disease (CKD) Stage 5 undergoing maintenance HF-HD were assigned to post-dilution OL-HDF (n = 17) or to remain on HF-HD (n = 16, control group) for 12 months.
Background And Objectives: Vascular calcification (VC) is common in CKD, but little is known about its prognostic effect on patients with nondialysis CKD. The prevalence of VC and its ability to predict death, time to hospitalization, and renal progression were assessed.
Design, Setting, Participants, & Measurements: The Study of Mineral and Bone Disorders in CKD in Spain is a prospective, observational, 3-year follow-up study of 742 patients with nondialysis CKD stages 3-5 from 39 centers in Spain from April to May 2009.