Publications by authors named "Cristina Candida Quarta"
Article Synopsis
- Immunoglobulin light chain amyloidosis is a rare disease that affects multiple organs such as the heart, kidneys, nerves, and digestive system, caused by improperly folded proteins that form harmful amyloid deposits.
- The prognosis for patients largely depends on the level of heart involvement and the effectiveness of treatment, with efforts to improve therapy development through partnerships like the one between the Amyloidosis Research Consortium and the FDA.
- The Cardiac Working Group aimed to identify key cardiovascular measures for clinical trials, focusing on factors like survival rates, hospitalization, and patient quality of life to improve treatment outcomes.
Aims: Cardiac amyloidosis remains a great challenge for the cardiologist. One of the three main aetiological forms, transthyretin-related hereditary amyloidosis (ATTRm), can present with several phenotypes, depending mainly on the specific mutation. We aimed to characterize the phenotype of patients with ATTRm due to Ile68Leu mutation, comparing them to patients with wild-type transthyretin amyloidosis (ATTRwt).
View Article and Find Full Text PDFAims: Wild-type transthyretin amyloidosis (ATTRwt) is mostly considered a disease predominantly of elderly male, characterized by concentric LV hypertrophy, preserved LVEF, and low QRS voltages. We sought to describe the characteristics of a large cohort of ATTRwt patients to better define the disease.
Methods And Results: Clinical findings of consecutive ATTRwt patients diagnosed at 2 centres were reviewed.