Publications by authors named "Cristina Camnasio"
Article Synopsis
- There is growing recognition that endometriosis can affect postmenopausal women, but there is still limited information available on its prevalence and clinical management in this demographic.
- Symptoms of endometriosis in menopausal patients can be vague and may appear at any stage, making accurate diagnosis challenging.
- Surgical excision remains the main treatment for symptomatic postmenopausal endometriosis, though there's ongoing debate about the use of hormone therapy due to potential risks, highlighting the need for more research in this area.
Objective: To investigate the role of BRCA1/2 mutations in early ovarian cancer (eOC) (International Federation of Gynecology and Obstetrics FIGO 2014 stage I-II), and its impact on prognosis after relapse.
Methods: In this multicenter retrospective study, clinical and survival data from high-grade serous (HGS)-eOC patients at presentation and recurrence were compared according to BRCA status: BRCA-mutated (BRCAmut) vs. BRCA wild-type (BRCAwt).
Risk-reducing surgery (RRS) is recommended in BRCA-mutated carriers because of their increased risk of developing ovarian cancer, while its role is still discussed for women harboring mutations in non- homologous repair genes. The aim of this study was to retrospectively evaluate the occurrence of pathological findings in a high-risk population undergoing RRS in San Matteo Hospital, Pavia between 2012 and 2022, and correlate their genetic and clinical outcomes, comparing them with a control group. The final cohort of 190 patients included 85 , 63 , 11 , 7 , 4 , 1 , 1 , 1 , 1 gene mutation carriers and 15 patients with no known mutation but with strong familial risk.
View Article and Find Full Text PDFBackground: The role of surveillance after surgery for stage IA-C grade 2 (G2) or grade 3 (G3) immature teratomas (ITs) is controversial with many guidelines advocating adjuvant chemotherapy. Here, we investigate the safety of surveillance in stage IA-C G1-3 ITs.
Methods: Clinicopathological data were analysed on postpubertal patients with stage I pure ITs in Multicenter Italian Trials in Ovarian Cancer centres and at Charing Cross Hospital, UK, between January 1985 and January 2018.