Publications by authors named "Cristina Arqueros"
Article Synopsis
- Deregulation of small non-coding RNAs (sncRNAs) is linked to metastasis in early-stage breast cancer, with RNA sequencing performed on samples from 60 patients.
- Analysis revealed that most sncRNAs were classified as small nucleolar RNA (snoRNA) and small nuclear RNA (snRNA), with no significant expression differences between tumor and sentinel lymph node samples.
- A specific signature of six snoRNAs was identified as potential markers for locoregional metastasis and patient outcomes, highlighting the need for further research to validate these findings in larger patient groups.
Currently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neoadjuvant setting. Tumour tissue and peripheral blood samples were retrospectively collected from 118 patients, and sTILs were evaluated.
View Article and Find Full Text PDFSecreted protein acidic and rich in cysteine (SPARC) expression has been proposed as a prognostic and predictive biomarker for some cancer types, but knowledge about the predictive value of polymorphisms in the context of neoadjuvant therapy for breast cancer (BC) is lacking. In 132 HER2-negative BC patients treated with neoadjuvant chemotherapy, we determined polymorphisms in the gene and analyzed their association with outcome. We also determined SPARC protein expression in tumor tissue.
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- The study investigates the connection between tumor-derived microRNAs (miRNAs) and their presence in the plasma of early breast cancer patients, focusing on whether these miRNAs can serve as noninvasive biomarkers for disease diagnosis.
- Analysis revealed that circulating miRNAs are generally downregulated compared to those found in tumor tissue and sentinel lymph nodes, but specific miRNAs like miR-643a-3p and miR-223 were upregulated in patients with positive lymph nodes.
- The findings indicate that certain circulating miRNAs could potentially serve as indicators of lymph node metastases in early breast cancer, but further research is needed to confirm these results and explore the biological roles of these miRNAs.
Cytotoxic T lymphocyte (CTLs) activation is an independent predictor of response to neoadjuvant chemotherapy (NACT) in breast cancer (BC) patients. Here, we go deeper into the function of CD8+ HLA-DR+ T cells from NACT treated HER2 negative BC patients. Flow cytometry analysis revealed that CD8+ HLA-DR+ T cell percentage was increased in NACT responder (R) compared to non-responder (NR) patients.
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- * A study investigated the expression profiles of circulating miRNAs in early breast cancer patients, linking their levels to sentinel lymph node (SLN) statuses confirmed by one-step nucleic acid (OSNA) analysis.
- * The research identified 16 differentially expressed miRNAs associated with positive SLN status, with implications for their potential use as markers for lymph node metastases, although further validation in larger studies is needed.
Global population growth and water resource scarcity are significant social problems currently being studied by many researchers focusing on finding new materials for water treatment. The aim is to obtain quality water suitable for drinking and industrial consumption. In this sense, an emergent class of crystalline porous materials known as Covalent-Organic Frameworks (COFs) offers a wide range of possibilities since their structures can be designed on demand for specific applications.
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- Research indicates that microRNAs (miRNAs) play a crucial role in the process of metastasis in cancer, particularly in breast cancer, though there's limited comparison between primary tumors and lymph node metastasis.
- In a study involving 60 early breast cancer patients, researchers found that specific miRNAs were differentially expressed in tumor samples and sentinel lymph nodes (SLNs), with significant findings like the up-regulation of miR-7641-2 and down-regulation of miR-1291 correlating with positive SLN status.
- The analysis suggests that miR-1291 may act as a tumor suppressor and points to its potential as a biomarker for SLN metastasis, encouraging further investigation in this area.
Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein of the extracellular matrix whose expression can be altered in malignant pancreatic cells and in the adjacent stromal fibroblasts. We evaluated the possible role of SPARC gene variants as prognostic markers for locally advanced and metastatic pancreatic cancer. We analyzed eight tagging single-nucleotide polymorphisms (TagSNPs) in the SPARC gene in 74 patients with pancreatic ductal adenocarcinoma treated with chemotherapy alone or combined with radiotherapy.
View Article and Find Full Text PDFStrongyloides stercoralis is an intestinal nematode that causes strongyloidiasis, which affects 30 to 100 million people worldwide. Risk factors for hyperinfection and disseminated disease include immunosuppressive drug therapy, human T-lymphotropic virus-1 (HTLV-1) infection, solid organ and bone marrow transplantation, hematologic malignant diseases, hypogammaglobulinemia, and severe malnutrition and associated conditions. The diagnosis can be difficult because a single stool examination fails to detect larvae in up to 70% of the cases, and the symptoms are nonspecific.
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