evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment.

Background: Coronavirus disease 2019 (COVID-19) has demonstrated several clinical manifestations which include not only respiratory system issues but also liver, kidney, and other organ injuries. One of these abnormalities is coagulopathies, including thrombosis and disseminated intravascular coagulation. Because of this, the administration of low molecular weight heparin is required for patients that need to be hospitalized.

COVID-19 liver and gastroenterology findings: An analysis of SARS-CoV-2 interactions with liver molecules.

Background: Coronavirus disease 19 (COVID-19) has not only been shown to affect the respiratory system, but has also demonstrated variable clinical presentations including gastrointestinal tract disorders. In addition, abnormalities in liver enzymes have been reported indicating hepatic injury. It is known that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might infect cells the viral receptor angiotensin-converting enzyme 2 (ACE2) which is expressed in several organs including the liver.