Efficacy of two endectoparasiticide products combining fipronil and (S)-methoprene or esafoxolaner with eprinomectin and praziquantel against fleas and intestinal helminths in cats naturally infested in Brazil.

Eprinomectin and praziquantel, nematodicide and cestodicide compounds, are both combined with the insecticide and acaricide compounds fipronil and (S)-methoprene in Frontline Protect/Broadline, or esafoxolaner in NexGard Combo. These topical feline endectoparasiticide products were tested for efficacy against fleas and intestinal helminths in a field trial in Brazil. Flea- and/or helminth-infested domestic cats were treated twice at a monthly interval following label instructions: 160 cats with Frontline Protect/Broadline and 165 cats with NexGard Combo.

Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics.

The aims of the present study were to evaluate the pharmacokinetic profile and efficacy of eprinomectin (EPM) against Rhipicephalus microplus in cattle of a new injectable form of EPM (Voss Performa®). The product was administered subcutaneously at a dose of 200 μg EPM/kg, in a single dose. The efficacy of EPM against R.

Acaricidal efficacy of topical formulation of fipronil in naturally infested dogs in Amazonic region, Brazil.

This study was conducted to show the effectiveness of a novel formulation of fipronil in a spot-on formulation for the therapeutic and preventive control of Rhipicephalus sanguineus in naturally infested dogs. Ticks on all dogs were counted at the moment of treatment and weekly after treatment (therapeutic efficacy) or infestation (preventive efficacy). The profile of the therapeutic efficacy for Rhipicephalus sanguineus suggested that the formulation was able to control the Ixodid species for at least 42 days after the treatment.