Differential Macrophage Subsets in Muscle Damage Induced by a K49-PLA from Bothrops jararacussu Venom Modulate the Time Course of the Regeneration Process.

Bothrops snakes cause around 80% of snakebites in Brazil, with muscle tissue damage as an important consequence, which may cause dysfunction on the affected limb. Bothropstoxin-I (BthTX-I) from Bothrops jararacussu is a K49-phospholipase A, involved in the injury and envenomation's inflammatory response. Immune system components act in the resolution of tissue damage and regeneration.