Publications by authors named "Cristiane Gomes da Silva"
The Omicron Lineages BA.1 and BA.2 ( SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub.
Viruses
March 2023
Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.
View Article and Find Full Text PDFPhylodynamic analysis of SARS-CoV-2 spread in Rio de Janeiro, Brazil, highlights how metropolitan areas act as dispersal hubs for new variants.
Microb Genom
September 2022
Article Synopsis
- During the first semester of 2021, Brazil faced a severe COVID-19 wave linked to the Gamma variant, with Delta variant cases emerging in July in Rio de Janeiro.
- Researchers analyzed over 1,600 genomic sequences of the Delta variant to understand its spread, noting its initial concentration in Rio de Janeiro city before reaching other areas.
- The Delta variant likely replaced Gamma due to a higher viral load, leading to increased case numbers but lower mortality rates, potentially aided by high vaccination rates in the region.
Emergence of Within-Host SARS-CoV-2 Recombinant Genome After Coinfection by Gamma and Delta Variants: A Case Report.
Front Public Health
March 2022
Article Synopsis
- This study presents the first documented case of intra-host recombination of SARS-CoV-2, involving two variants of concern: AY.33 (Delta) and P.1 (Gamma).
- Using next-generation sequencing, the researchers identified six recombinant regions across the SARS-CoV-2 genome, particularly in the spike and nucleocapsid genes, showcasing a mix of mutations from both variants.
- The findings highlight a potential public health risk, as the emergence of new recombinant viruses could complicate COVID-19 management and response efforts.
Genomic Surveillance Tracks the First Community Outbreak of the SARS-CoV-2 Delta (B.1.617.2) Variant in Brazil.
J Virol
January 2022
Turnover of SARS-CoV-2 Lineages Shaped the Pandemic and Enabled the Emergence of New Variants in the State of Rio de Janeiro, Brazil.
Viruses
October 2021
In the present study, we provide a retrospective genomic epidemiology analysis of the SARS-CoV-2 pandemic in the state of Rio de Janeiro, Brazil. We gathered publicly available data from GISAID and sequenced 1927 new genomes sampled periodically from March 2021 to June 2021 from 91 out of the 92 cities of the state. Our results showed that the pandemic was characterized by three different phases driven by a successive replacement of lineages.
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