Publications by authors named "Cristiane C Singulane"
Right ventricular thrombi (RVTs) have been almost exclusively studied in patients with pulmonary embolism (PE). The implications of an isolated RVT, a finding typically encountered on transthoracic echocardiography (TTE), are lacking. In this study, we sought to identify the echocardiographic and clinical features associated with the presence of RVTs.
View Article and Find Full Text PDFBackground: Left atrial volume (LAV) has prognostic value. Guidelines propose indexation to body surface area (BSA), however studies demonstrate this can overcorrect for body size. Limited studies investigate indexation across different ethnicities.
View Article and Find Full Text PDFBackground: Normal values for three-dimensional (3D) right ventricular (RV) size and function are not well established, as they originate from small studies that involved predominantly white North American and European populations, did not use RV-focused views, and relied on older 3D RV analysis software. The World Alliance Societies of Echocardiography study was designed to generate reference ranges for normal subjects around the world. The aim of this study was to assess the worldwide capability of 3D imaging of the right ventricle and report size and function measurements, including their dependency on age, sex, and ethnicity.
View Article and Find Full Text PDFAims: While cardiac magnetic resonance (CMR) is often obtained early in the evaluation of suspected cardiac amyloidosis (CA), it currently cannot be utilized to differentiate immunoglobulin (AL) and transthyretin (ATTR) CA. We aimed to determine whether a novel CMR and light-chain biomarker-based algorithm could accurately diagnose ATTR-CA.
Methods And Results: Patients with confirmed AL or ATTR-CA with typical late gadolinium enhancement (LGE) and Look-Locker pattern for CA on CMR were retrospectively identified at three academic medical centres.
Background: Left ventricular (LV) circumferential strain has received less attention than longitudinal deformation, which has recently become part of routine clinical practice. Among other reasons, this is because of the lack of established normal values. Accordingly, the aim of this study was to establish normative values for LV circumferential strain and determine sex-, age-, and race-related differences in a large cohort of healthy adults.
View Article and Find Full Text PDFArticle Synopsis
- Transthoracic echocardiography is a key imaging tool for assessing cardiac function in COVID-19 patients, and this study aimed to see if AI analysis could predict mortality better than human experts.
- Researchers evaluated 870 patients, finding a mortality rate of 27.4% after about 230 days; AI analysis showed lower variability and greater accuracy in predicting mortality compared to manual assessments.
- AI-derived metrics of left ventricular ejection fraction (LVEF) and longitudinal strain (LVLS) were significant predictors of mortality, outperforming manual measurements and being more closely correlated with other key biomarkers of acute disease.
Article Synopsis
- Cardiac amyloidosis (CA) leads to abnormal protein deposits affecting both the left and right atria, resulting in dysfunction, particularly in the right atrial (RA) structure and function.
- A study involving 118 patients with CA revealed that those affected had significantly larger RA volumes and impaired functional metrics compared to healthy controls, indicating notable RA involvement.
- Analysis identified that certain RA parameters (reservoir and conduit strains) correlate with mortality, underscoring the importance of RA assessment in evaluating prognosis for CA patients.
Article Synopsis
- Progressive tricuspid regurgitation (TR) leads to poorer health outcomes, emphasizing the need for better assessment of its severity and morphology.
- Advances in percutaneous interventions for TR treatment highlight the importance of accurately understanding TR's causes and severity for choosing appropriate therapies.
- The review discusses modern ideas about tricuspid valve structure, TR causes, mechanisms, and the latest echocardiographic methods for grading TR severity.
Background: COVID-19 infection is known to cause a wide array of clinical chronic sequelae, but little is known regarding the long-term cardiac complications. We aim to report echocardiographic follow-up findings and describe the changes in left (LV) and right ventricular (RV) function that occur following acute infection.
Methods: Patients enrolled in the World Alliance Societies of Echocardiography-COVID study with acute COVID-19 infection were asked to return for a follow-up transthoracic echocardiogram.
Article Synopsis
- The study compared echocardiographic features and clinical characteristics of 234 patients admitted during the first and second waves of the pandemic to identify factors associated with mortality.
- Findings revealed a significant reduction in all-cause mortality from 35.2% in the first wave to 14.7% in the second, while certain echocardiographic measures were worse in the first wave, though demographic factors remained constant across the two waves.
Transillumination (TI) is a new 3D rendering tool that uses a freely movable virtual light source to enhance depth, contours, and image detail. The TI model was recently modified to allow the operator adjust the degree of transparency of both cardiac and extra-cardiac structures. While the addition of transparency was shown to significantly improve quality in 3D transesophageal imaging, this has not yet been shown for transthoracic (TTE) imaging.
View Article and Find Full Text PDFObjective: The present study refers to a determination of the preoperative B-type natriuretic peptide is a predictor of short-term all-cause mortality in patients undergoing on-pump coronary artery bypass graft surgeries.
Methods: Two hundred and twenty-one patients undergoing on-pump coronary artery bypass graft surgeries were evaluated prospectively during a 30-day postoperative follow-up period. Serum B-type natriuretic peptide concentration was measured without a 24-hour period prior to the surgical procedure and the value obtained was correlated with a short-term all-cause mortality.
Eltrombopag is a new thrombomimetic medication approved for the treatment of immune thrombocytopenia. There are very few reports on the use of eltrombopag in patients with thrombocytopenia associated with sytemic lupus.We present a recent case of a patient with lupus with severe thrombocytopenia refractory to conventional therapy and full recovery with the use of eltrombopag.
View Article and Find Full Text PDFBackground And Aims: The characterization of candidate gene polymorphisms in elderly populations is an important tool for the identification of risk factors for age-related diseases and conditions. We aimed to genotype the APOE polymorphisms (rs429358 and rs7412), rs61886492 (1561C>T) and rs202720 of GCPII gene and rs3918242 (-1562C>T) of MMP9 gene in an older-adult/elderly cohort from Cuiabá city, Mato Grosso Brazil as well as to characterize risk factors for morbidities and conditions affecting this cohort.
Methods: The studied population consisted of 570 subjects from Cuiabá city, Brazil, who were subjected to clinical interviews and blood collection for laboratory examinations and DNA extraction.
Background And Aims: Peroxisome proliferator-activated receptor α is a nuclear receptor involved in the regulation of several biochemical pathways. Polymorphisms within its gene have been associated with several metabolic traits. We aimed to investigate the association of L162V and Intron 7G>C polymorphisms with serum level markers and common morbidities affecting an older adult/elderly cohort from Cuiaba City, Mato Grosso State, Brazil, as well as to compare the results with a previously studied population from São Paulo City, Brazil.
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