Publications by authors named "Cristiane Bastos de Mattos"
Article Synopsis
- - Diazepam (DZP) is a sedative used for anxiety and sleep, but it can have negative side effects; researchers aimed to develop nanocapsules to improve its effectiveness and reduce these side effects.
- - The study involved creating and testing DZP nanocapsules using the nanoprecipitation method, ensuring they were stable and effective through various evaluations, including toxicity tests on C. elegans and mice.
- - Results showed that the nanocapsules safely carried DZP, had high drug entrapment efficiency, and produced a hypnotic effect at lower doses without toxicity, making them a promising alternative to traditional DZP.
Article Synopsis
- Depression is a common mental health issue, and this research investigates the use of nanotechnology to enhance the delivery and effectiveness of paroxetine hydrochloride, an antidepressant.
- The study developed liposomes and nanocapsules to carry the drug, with findings showing that the particle size ranged from 121.81 to 310.73 nm and drug release was slower with liposomes compared to nanocapsules.
- Experimental tests on mice indicated that both nanostructures effectively reduced signs of depression and anxiety, suggesting they could be useful for improving paroxetine's therapeutic effects at lower doses.
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect.
Pharmacol Rep
October 2022
Background: Vortioxetine hydrobromide (VXT), a new therapeutic option in the treatment of major depressive disorder, is a poorly soluble drug, and instability under stress conditions has been reported. The aim of the present study was to prepare VXT liposomes (VXT-Ls) with an antidepressant-like effect, to improve drug stability and reduce toxicity of the free drug.
Methods: Liposomes were prepared using the thin lipid film hydration method and properly characterized.
Nanoemulsions containing a synthetic chalcone as an alternative for treating cutaneous leshmaniasis: optimization using a full factorial design.
Int J Nanomedicine
September 2016
Nanoemulsions are drug delivery systems that may increase the penetration of lipophilic compounds through the skin, enhancing their topical effect. Chalcones are compounds of low water solubility that have been described as promising molecules for the treatment of cutaneous leishmaniasis (CL). In this context, the aim of this work was to optimize the development of a nanoemulsion containing a synthetic chalcone for CL treatment using a 2(2) full factorial design.
View Article and Find Full Text PDFThe aim of this study was to optimize topical nanoemulsions containing genistein, by means of a 23 full factorial design based on physicochemical properties and skin retention. The experimental arrangement was constructed using oil type (isopropyl myristate or castor oil), phospholipid type (distearoylphosphatidylcholine [DSPC] or dioleylphosphaditylcholine [DOPC]), and ionic cosurfactant type (oleic acid or oleylamine) as independent variables. The analysis of variance showed effect of third order for particle size, polydispersity index, and skin retention of genistein.
View Article and Find Full Text PDFPrevalence of 4977bp deletion in mitochondrial DNA from patients with chronic kidney disease receiving conservative treatment or hemodialysis in southern Brazil.
Ren Fail
May 2008
Background: Damage to mitochondrial DNA (mtDNA) has been described in patients with chronic kidney disease (CKD). The presence of mtDNA 4977bp deletion in many different tissues can serve as a marker of this damage. However, no attempt has been made to detect the presence of mtDNA 4977bp in blood cells of patients with CKD.
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