Publications by authors named "Cristiana Fernandes"

Orthoses are commonly used for treating injuries to improve the quality of life of patients, with customized orthoses offering significant benefits. Additive manufacturing, especially fused deposition modelling, enhances these benefits by providing faster, more precise, and more comfortable orthoses. The present study evaluates nine polymeric materials printed in horizontal and vertical directions by assessing their performance through compressive, flexural, and tensile tests.

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When a limb suffers a fracture, rupture, or dislocation, it is traditionally immobilized with plaster. This may induce discomfort in the patient, as well as excessive itching and sweating, which creates the growth of bacteria, leading to an unhygienic environment and difficulty in keeping the injury clean during treatment. Furthermore, if the plaster remains for a long period, it may cause lesions in the joints and ligaments.

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The increasing use of molybdenum disulfide (MoS) nanoparticles (NPs) raises concerns regarding their accumulation in soil ecosystems, with limited studies on their impact on soil organisms. Study aim: To unravel the effects of MoS nanosheets (two-dimensional (2D) MoS NPs) and bulk MoS (156, 313, 625, 1250, 2500 mg/kg) on and . The organisms' survival and avoidance behavior remained unaffected by both forms, while reproduction and DNA integrity were impacted.

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Neural tissue-related illnesses have a high incidence and prevalence in society. Despite intensive research efforts to enhance the regeneration of neural cells into functional tissue, effective treatments are still unavailable. Here, a novel therapeutic approach based on vertically aligned carbon nanotube forests (VA-CNT forests) and periodic VA-CNT micropillars produced by thermal chemical vapor deposition is explored.

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Ankle-foot orthoses (AFO) are prescribed to improve the patient's quality of life. Supporting weak muscles or restraining spastic muscles leads to smoother and more stable locomotion. Commonly, AFO are made using thermoplastic vacuum forming, which requires a long time for production and has limited design options.

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Biomimetics offers excellent prospects for design a novel generation of improved biomaterials. Here the controlled integration of graphene oxide (GO) derivatives with a 3D marine spongin (MS) network is explored to nanoengineer novel smart bio-based constructs for bone tissue engineering. The results point out that 3D MS surfaces can be homogeneously coated by layer-by-layer (LbL) assembly of oppositely charged polyethyleneimine (PEI) and GO.

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Article Synopsis
  • Anti-TNF-α therapy, like adalimumab, is commonly used to treat various rheumatologic diseases, but it can increase the risk of opportunistic infections, making latent tuberculosis screening essential before starting treatment.
  • A 62-year-old man with psoriatic arthritis was treated with adalimumab and initially tested negative for latent tuberculosis; however, he later experienced symptoms of systemic infection and was diagnosed with disseminated tuberculosis affecting multiple organs, including the brain.
  • The case highlights the difficulties in diagnosing tuberculosis, especially in patients on immunosuppressive therapy, and emphasizes the need for careful monitoring and management.
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Article Synopsis
  • The causes of pulmonary nodules can be diverse, with malignant ones being the most critical to identify quickly for treatment.
  • A 50-year-old man with chest pain was initially misdiagnosed with pneumonia based on CT scan findings, which actually showed a suspicious lung nodule.
  • Even with advanced diagnostic techniques, errors can occur, leading to misdiagnoses, highlighting the challenges in accurately diagnosing pulmonary nodules before surgery.
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Due to the extremely high incidence of lesions and diseases in aging population, it is critical to put all efforts into developing a successful implant for osteochondral tissue regeneration. Many of the patients undergoing surgery present osteochondral fissure extending until the subchondral bone (corresponding to a IV grade according to the conventional radiographic classification by Berndt and Harty). Therefore, strategies for functional tissue regeneration should also aim at healing the subchondral bone and joint interface, besides hyaline cartilage.

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Unlabelled: Splenosis is a benign condition which results from the self-implantation of splenic tissue on intra or extraperitoneal surfaces, after splenic trauma or splenectomy. Patients are usually asymptomatic but may present with varied symptoms related to the implantation site. The diagnosis is a challenge because abdominal splenosis can mimic several diseases, including neoplasm.

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Acrylamide (AA), a molecule which potentially increases the risk of developing cancer, is easily formed in food rich in carbohydrates, such as biscuits, wafers, and breakfast cereals, at temperatures above 120 °C. Thus, the need to detect and quantify the AA content in processed foodstuffs is eminent, in order to delineate the limits and mitigation strategies. This work reports the development and validation of a high-resolution mass spectrometry-based methodology for identification and quantification of AA in specific food matrices of biscuits, by using LC-MS with electrospray ionization and Orbitrap as the mass analyser.

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Osteoarthritis (OA) is a degenerative disease, promoted by abnormal chronic mechanical loading over the joint, for instance, due to excessive body mass. Patients frequently report pain, fatigue, and limitations in specific functional daily activities. Regarding the treatment of OA, two nonpharmacological options are available.

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