Publications by authors named "Cristian Sorin Hariga"

Radiation injuries, particularly those resulting from therapeutic or accidental exposure, present complex challenges for medical management. These injuries can manifest localized skin damage or extend to deeper tissues, presenting as various clinical entities that require treatment strategies, ranging from conservative management to complex surgical interventions. Radiation treatment constitutes a fundamental component of neoplastic management, with nearly two out of three oncological instances undergoing it as an element of their therapeutic strategy.

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Melanoma is one of the most aggressive forms of skin cancer. While most melanomas have a discernible primary site, a small subset, approximately 3.2%, present as a metastatic disease without an identifiable primary origin, a condition known as melanoma of unknown primary (MUP).

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  • The Buschke-Löwenstein tumor (BLT) is a rare, exophytic tumor linked to low-risk HPV strains, primarily appearing as a large, cauliflower-like growth in genital areas, which can be locally aggressive and has a notable recurrence rate.
  • A 68-year-old patient with multiple health issues presented with a sizable tumor causing erectile dysfunction and urinary problems, which was successfully surgically excised with reconstruction.
  • Histopathological analysis confirmed the diagnosis, and the patient's recovery underscores the importance of early diagnosis and surgical intervention to manage BLT and prevent complications like malignancy and recurrence.
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Background: Severe burns pose significant therapeutic challenges due to their complex pathophysiology, the potential for life-threatening complications, long-term sequelae and the need for a multidisciplinary approach. In this retrospective study, we aimed to comprehensively analyze burns involving over 50% of the total body surface area (TBSA) treated in our institution over six years.

Materials And Methods: We performed a retrospective study including 91 patients.

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: Hand septic arthritis is a potentially debilitating condition that can significantly affect patient functionality and quality of life. Understanding the demographic, clinical, and microbiological characteristics of this condition is crucial for its effective treatment and management. This study aimed to analyze the demographic and clinical profiles of patients with hand septic arthritis, to identify common microbial pathogens, and to evaluate the impact of various factors on clinical course and treatment outcomes.

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  • * Effective management of cerebral metastases often requires a combination of approaches, including local treatments (like surgery and radiotherapy) and systemic therapies to improve patient outcomes and quality of life.
  • * A case study highlights the need for tailored treatment plans, demonstrating how a delayed diagnosis and rapid progression of melanoma can complicate care and emphasizing the importance of a multidisciplinary approach in managing these complex cases.
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  • The field of transplantation has advanced significantly since the first hand transplant in 1998, particularly in vascularized composite allotransplantation (VCA), which faces challenges like the need for lifelong immunosuppressive therapy.
  • Current research aims to improve immunosuppressive strategies to reduce toxicity and foster donor-specific tolerance, emphasizing the role of costimulatory signals in T cell activation.
  • This review summarizes data on costimulatory blockade as a potential method to prevent organ rejection and enhance the success of VCA, exploring new techniques for safer transplantation procedures.
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  • Burn injuries lead to serious trauma with high morbidity and mortality, making prompt management essential for improving patient outcomes, particularly focusing on biological parameters like thrombocytopenia.
  • A two-year study of 90 severely burned patients revealed that thrombocytopenia was linked to a worse prognosis, as those with low platelet counts had higher mortality rates, especially in conjunction with other severe burn characteristics.
  • The findings suggest thrombocytopenia can serve as an early warning sign for complications and may help predict outcomes in patients with severe burns, especially in those experiencing sepsis.
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Burn patients manifest all components of Virchow's triad, amplifying the concern for venous thromboembolism (VTE). Routine prophylaxis for VTE remains a subject of debate, with the central concern being the occurrence of associated adverse events. We conducted a five-year retrospective study on burn patients admitted to our burn center.

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Background: Skin grafting is a helpful instrument in a plastic surgeon's arsenal. Several types of dressings were designed to facilitate the process of graft integration. Negative-pressure wound therapy is a proven dressing method, enhancing graft survival through several mechanisms: aspiration of secretions, stimulation of neoangiogenesis, and promotion of an anti-inflammatory environment.

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Benign and malignant cartilaginous bone tumors of the hand are rare findings, however representing a particular pathology due to the capacity to induce significant functional impairment. Even though a large proportion of tumors of the hand and wrist are benign, these may present destructive characteristics, deforming adjacent structures until compromising function. The most appropriate surgical approach for most benign tumors is intralesional lesion resection.

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Background And Objectives: Nowadays, breast cancer treatment spans from simple lesion excision to complex management including surgery (mastectomy with or without axillary lym-phadenectomy) and adjuvant treatment (chemotherapy, radiotherapy, hormonal therapy and im-munotherapy). Lately, breast reconstruction has become part of the breast cancer approach, but, while its physical and emotional benefits are undisputed, it comes with its own set of risks and complications, especially when delayed breast reconstruction after radiotherapy is performed. This paper aims to present our experience on the effects of radiotherapy in conjunction with de-layed alloplastic breast reconstruction.

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Solitary fibrous tumor (SFT) is a rare neoplasia. Now classified as SFT, it was first described in 1942 as "hemangiopericytoma" (HPC), and its origin was supposed to be the pericytes. The location outside the pleura is considered uncommon and the tumor situation on the thigh is much more unusual.

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