Publications by authors named "Cristian Sadalis Santos-Lopez"
Background: Bacteriophage therapy is becoming part of mainstream Western medicine since antibiotics of clinical use tend to fail. It involves applying lytic bacteriophages that self-replicate and induce cell lysis, thus killing their hosts. Nevertheless, bacterial killing promotes the selection of resistant clones which sometimes may exhibit a decrease in bacterial virulence or antibiotic resistance.
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- Social cheating involves the use of costly public goods, such as exoproteases, which some bacteria exploit without contributing themselves, specifically observed in Pseudomonas aeruginosa.
- In the environmental strain ID4365, nonexoprotease producers exhibit social cheating behaviors due to a mutation preventing LasR expression, leading to population collapses during continuous growth in casein.
- The study reveals that inducing a prophage in ID4365 during growth may heighten the costs of social cheating, ultimately contributing to the population's decline and showcasing the role of temperate phages in these dynamics.