Publications by authors named "Cristian Orellana Chea"
Antibiotic Consumption During the Coronavirus Disease 2019 Pandemic and Emergence of Carbapenemase-Producing Klebsiella pneumoniae Lineages Among Inpatients in a Chilean Hospital: A Time-Series Study and Phylogenomic Analysis.
Kasim Allel Anne Peters José Conejeros José R W Martínez Maria Spencer-Sandino Cristian Orellana Chea
Clin Infect Dis
July 2023
Article Synopsis
- The study evaluated the impact of COVID-19 on antimicrobial use and resistance in a hospital in Santiago, Chile, from 2018 to 2022, comparing periods before and after the pandemic onset.
- Antimicrobial use significantly increased post-pandemic for broad-spectrum β-lactams, carbapenems, and colistin, along with a rise in carbapenem-resistant Enterobacterales (CRE), particularly carbapenemase-producing species.
- The findings indicate a need for improved infection control and antimicrobial stewardship due to the emergence of new genomic lineages of resistant bacteria following the pandemic.