Publications by authors named "Cristian G Sanchez La Rosa"
An association of deletions in the IKZF1 gene (IKZF1del) with poor prognosis in acute lymphoblastic leukemia (ALL) has been demonstrated. Additional deletions in other genes (IKZF1plus) define different IKZF1del subsets. We analyzed the influence of IKZF1del and/or IKZF1plus in the survival of children with ALL.
View Article and Find Full Text PDFBackground: Infant acute lymphoblastic leukemia (ALL) is an infrequent disease characterized by clinical and biological features related to poor prognosis. Adapted therapies were designed without a clear consensus regarding the best treatment options. We aimed to compare the outcome between infant ALL cases receiving Interfant versus BFM-based protocols.
View Article and Find Full Text PDFIntroduction: Children with Down syndrome (DS) more commonly have acute lymphoblastic leukemia (ALL) and a lower survival rate than those without Down syndrome (WDS). We analyzed the clinical, demographic, and biological characteristics and treatment response of children with DS-ALL versus those WDS-ALL. Patients and methods: Patients with ALL between January 1990 and November 2016.
View Article and Find Full Text PDFArticle Synopsis
- - Childhood acute leukemias and lymphomas have high survival rates, but can lead to second neoplasms (SN), with 1% of patients developing SN over nearly 30 years of study.
- - Among the 34 patients with SN, the most common types included acute leukemias and various solid tumors, with a significantly longer latency period for solid tumors compared to hematological malignancies.
- - Treatment of SN, considering previous therapy doses, resulted in a 67.6% complete remission rate, indicating that patients can have survival rates similar to those diagnosed with new cancers.