Aromatic linker variations in novel dopamine D and D receptor ligands.

Dopamine D-like receptors, especially D and D receptor subtypes, are important targets of antipsychotic agents. Many of these antipsychotics share an aliphatic linker element between a protonable amine group and an acyl-like moiety. Here, we have modified this aliphatic linker into phenylmethyl and phenylethyl linkers substituted in different positions.