Publications by authors named "Cristian Coriano-Ortiz"
Article Synopsis
- Molecules that can be controlled by light, like the LOVdeg tag, enable scientists to regulate cell behavior in a precise way using light.
- The LOVdeg tag allows for the targeted degradation of specific proteins when exposed to blue light, making it versatile for various applications.
- This system has been tested with different proteins and shows promise in enhancing other optogenetic tools, illustrating its potential in metabolic engineering and advancing bacterial optogenetics.
Molecular tools for optogenetic control allow for spatial and temporal regulation of cell behavior. In particular, light controlled protein degradation is a valuable mechanism of regulation because it can be highly modular, used in tandem with other control mechanisms, and maintain functionality throughout growth phases. Here, we engineered LOVdeg, a tag that can be appended to a protein of interest for inducible degradation in using blue light.
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