Unusual tumour of the anterior mediastinum: Intrathymic bronchogenic cyst mimicking a thymoma.

Bronchogenic cysts are rare congenital cystic lesions. Their occurrence in the anterior mediastinum as intrathymic bronchogenic cyst is extremely uncommon. These cysts present as mediastinal masses, and are generally asymptomatic and often diagnosed incidentally.

Computational pathology identifies a low B-cell content in the tumour microenvironment as a predictor of adverse outcome in patients with classic Hodgkin lymphoma treated with ABVD.

Aims: The prognostic impact of B lymphocytes surrounding Hodgkin and Reed Sternberg (HRS) cells in classic Hodgkin lymphoma (cHL) and pathogenic variants in genes associated with apoptosis regulation remains undefined.

Methods: We have quantified the proportion of B lymphocytes in tumour microenvironment (TME) in 220 diagnostic slides from 110 cHL patients applying computational pathology (CP) and sequenced cases using a targeted panel including 47 genes recurrently mutated in mature B-cell neoplasms. Kaplan-Meier estimators and multivariate Cox regression on overall survival (OS) and progression-free survival (PFS) were assessed following the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis guidelines.

Diffuse intestinal ganglioneuromatosis. A post mortem diagnosed challenging case.

Intestinal ganglioneuromatosis (GN) is a benign disease of the autonomic nervous system characterized by hyperplasia of intramural plexuses of the gastrointestinal tract and enteric nerve fibers. Next, we expose an intestinal ganglioneuromatosis case that was difficult to diagnose despite an exhaustive evaluation, for further understanding of the disease.