Publications by authors named "Cristel Vanessa Camacho"
Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice between NHEJ and HR DNA repair pathways is made. Although CDKs are known to control initiation of resection, their role in regulating long-range resection remains elusive. Here we show that CDKs 1/2 phosphorylate the long-range resection nuclease EXO1 at four C-terminal S/TP sites during S/G2 phases of the cell cycle.
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- High atomic number and energy ions (HZE particles) can increase the risk of cancer for astronauts in space, but similar particles are used to treat cancer on Earth.
- Research shows that human cells struggle to repair DNA damage caused by these HZE particles, especially when using aluminum or lead shielding, while polyethylene shielding helps repair the damage better.
- The study found that the body's response to DNA damage caused by these ions is complex, involving important proteins like p53, and that PE helps reduce harmful reactions after the damage occurs.